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Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models. | LitMetric

AI Article Synopsis

  • TNF is a key cytokine in immunology, leading to breakthroughs in understanding immune responses despite its limited clinical use.
  • Anti-cytokine therapies targeting TNF have been highly effective for various diseases, but blocking TNF can have negative side effects due to its crucial role in host defense.
  • The review focuses on research using genetically engineered mice to explore TNF's functions, highlighting the importance of transgenic and knockout models in understanding its effects.

Article Abstract

TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which targets this single molecule, has enjoyed astounding success in treatment of a growing number of human diseases. However, since TNF mediates unique physiologic functions, in particular those related to host defense, TNF blockade may result in unwanted consequences. Much of our understanding about TNF intrinsic functions in the body, as well as about consequences of its overexpression and ablation, is based on studying phenotypes of various genetically engineered mice. Here we review mouse studies aimed at understanding TNF physiologic functions using transgenic and knockout models, and we discuss additional mouse models that may be helpful in the future.

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Source
http://dx.doi.org/10.1016/j.cytogfr.2008.04.010DOI Listing

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