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Emerging Biomarkers of Acute Myocardial Infarction, An Overview of the Newest MicroRNAs.
Galen Med J
May 2023
Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Globally, acute myocardial infarction (AMI) is the leading cause of death. Early and precise diagnosis is essential for medical care to enhance prognoses and reduce mortality. The diagnosis of AMI relies primarily on conventional circulating biomarkers.
View Article and Find Full Text PDFMncR: Late Integration Machine Learning Model for Classification of ncRNA Classes Using Sequence and Structural Encoding.
Int J Mol Sci
May 2023
Institute of Bioinformatics, University Medicine Greifswald, Walther-Rathenau Str. 48, 17489 Greifswald, Germany.
Non-coding RNA (ncRNA) classes take over important housekeeping and regulatory functions and are quite heterogeneous in terms of length, sequence conservation and secondary structure. High-throughput sequencing reveals that the expressed novel ncRNAs and their classification are important to understand cell regulation and identify potential diagnostic and therapeutic biomarkers. To improve the classification of ncRNAs, we investigated different approaches of utilizing primary sequences and secondary structures as well as the late integration of both using machine learning models, including different neural network architectures.
View Article and Find Full Text PDFNew Horizons of Macrophage Immunomodulation in the Healing of Diabetic Foot Ulcers.
Pharmaceutics
September 2022
Oneness Biotech Co., Ltd., Taipei 106, Taiwan.
Diabetic foot ulcers (DFUs) are one of the most costly and troublesome complications of diabetes mellitus. The wound chronicity of DFUs remains the main challenge in the current and future treatment of this condition. Persistent inflammation results in chronic wounds characterized by dysregulation of immune cells, such as M1 macrophages, and impairs the polarization of M2 macrophages and the subsequent healing process of DFUs.
View Article and Find Full Text PDFmiRacle of microRNA-Driven Cancer Nanotherapeutics.
Cancers (Basel)
August 2022
Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA.
MicroRNAs (miRNAs) are non-protein-coding RNA molecules 20-25 nucleotides in length that can suppress the expression of genes involved in numerous physiological processes in cells. Accumulating evidence has shown that dysregulation of miRNA expression is related to the pathogenesis of various human diseases and cancers. Thus, stragegies involving either restoring the expression of tumor suppressor miRNAs or inhibiting overexpressed oncogenic miRNAs hold potential for targeted cancer therapies.
View Article and Find Full Text PDFThe Involvement of Neutrophils in the Pathophysiology and Treatment of Osteoarthritis.
Biomedicines
July 2022
Department of Orthopaedic Surgery, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI 49008, USA.
Osteoarthritis (OA) is a chronic disability that significantly impairs quality of life. OA is one of the most prevalent joint pathologies in the world, characterized by joint pain and stiffness due to the degeneration of articular cartilage and the remodeling of subchondral bone. OA pathogenesis is unique in that it involves simultaneous reparative and degradative mechanisms.
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