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Associations Between Walking Pace, APOE-ε4 Genotype, and Brain Health in Middle-Aged to Older Adults.
Med Sci Sports Exerc
January 2025
Department of Psychology, University of Southern California, CA.
Poor physical function and possession of the e4 allele of the apolipoprotein E (APOE) gene are each associated with increased dementia risk, but it is unclear how these exposures interact to influence brain health. Purpose: To investigate whether self-reported walking pace (a marker of physical function) and the presence of APOE-ε4 allele interact to modify brain health outcomes. Methods: We used data from a prospective cohort study of middle-aged to older adults from the UK Biobank who self-reported walking pace (slow or steady-to-brisk), and who were initially free of dementia (n = 415,110).
View Article and Find Full Text PDFDream and its interpretation: scientific perspective.
Intern Emerg Med
January 2025
Neurology Unit, Internal Medicine Department, Alex Ekwueme Federal University Teaching Hospital, Abakaliki (AEFUTHA), Ebonyi State, Nigeria.
Dream is a mental activity that occurs during sleep. Its interpretation is common practice in many African cultures and this role is vested in unqualified persons, such as diviners, priests, and healers. Their unprofessional activities have led to dangerous consequences, such as anxiety, depression, loss of material possessions, bodily harm, family, or community conflicts, or even death.
View Article and Find Full Text PDFCriminal legal penalties, substance use, and overdose: a concept mapping study examining Colorado's criminal legal penalties.
BMC Glob Public Health
January 2025
Division of General Internal Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, 80045 CO, USA.
Background: In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk. We aimed to evaluate the relationship between Colorado's increased drug-related criminal legal penalties, risk of overdose, and substance use patterns.
Methods: We used concept mapping - a mixed-methods approach used to develop a conceptual understanding of an issue from a community lens - to engage with people with living and/or lived experience with the criminal legal system, substance use, and/or overdose, their loved ones, and service providers.
Scientific imperialism and the American Equatorial Islands Colonization Project, 1935-1942.
Hist Sci
December 2024
Hacettepe University, Turkey.
Between 1935 and 1942, a total of 130 men, aged seventeen to twenty-four, mostly of indigenous Hawaiian heritage, colonized Howland, Baker, and Jarvis Islands for the United States, in rotation, over the course of twenty-six expeditions. As part of the American Equatorial Islands Colonization Project (AEICP), they compiled meteorological data, observed and recorded the natural life of their surroundings, collected specimens for the Bishop Museum in Honolulu, mapped the islands, and built a landing strip on Howland for Amelia Earhart. In doing so, they confirmed U.
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