AI Article Synopsis
- The study aimed to evaluate atrial myocardial perfusion in patients with lone recurrent atrial fibrillation (LRAF), an area with limited previous research.
- Despite no significant differences in baseline blood flow velocity between LRAF patients and control subjects, significant reductions in peak blood flow and coronary flow reserve were noted in the LAFB of LRAF patients compared to controls.
- The findings suggest that patients with LRAF experience specific microvascular dysfunction, revealing isolated perfusion abnormalities linked to this condition.
Article Abstract
Objectives: The purpose of this study was to assess atrial myocardial perfusion in patients with lone recurrent atrial fibrillation (LRAF).
Background: Although acute atrial ischemia has been implicated in the pathogenesis of atrial fibrillation, there are few data concerning human atrial myocardial perfusion and none for patients with LRAF.
Methods: Sixteen patients with LRAF and 15 control subjects with suitable coronary anatomy underwent time-averaged peak coronary blood flow velocity (APV) measurements (cm/s), using a Doppler guidewire in the proximal left circumflex coronary artery (LCx) and in the left atrial circumflex branch (LACB), at baseline (b) and after adenosine administration to achieve maximal hyperemia (h). Coronary flow reserve was defined as h-APV/b-APV.
Results: Although there were no statistically significant differences in b-APV between patients with LRAF and control subjects or between the LACB and LCx, there were significant group (p = 0.002), artery (p = 0.001), and interaction (p < 0.001) effects at maximal hyperemia. In patients with LRAF, the h-APV and coronary flow reserve of the LACB (30.4 +/- 9.5 cm/s and 2.2 +/- 0.4, respectively) were significantly lower than in the LACB of the control subjects (45.8 +/- 12.8 cm/s [p < 0.001] and 2.9 +/- 0.5 [p = 0.001], respectively) or in the patients' LCx (43.0 +/- 10.9 cm/s [p = 0.001] and 3.1 +/- 0.6 [p < 0.001], respectively).
Conclusions: This study confirms for the first time isolated atrial myocardial perfusion abnormalities in patients with LRAF and coronary flow reserve impairment, indicating that microvascular dysfunction is a pathophysiological substrate associated with this arrhythmia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jacc.2008.01.055 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation.
J Geriatr Cardiol
November 2023
Department of Cardiology, the Second Medical Center, National Clinical Research Center of Geriatric Disease, Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, Chinese PLA General Hospital, Beijing, China.
Background: Catheter-based pulmonary vein isolation (PVI) is an effective and well-established intervention for symptomatic paroxysmal atrial fibrillation (PAF). Nevertheless, late recurrences of atrial fibrillation (LRAF) occurring during 3 to 12 months are common, and the underlying mechanisms remain elusive. Circular RNAs (circRNAs) in atrial tissue have been linked to the pathophysiological mechanisms and progression of PAF in a few studies.
View Article and Find Full Text PDFRatio of P-Wave Duration to P-Wave Amplitude and Left Atrial Remodeling: Insights from Electrophysiological Findings and Myocardial Injury After Cryoballoon Ablation.
Am J Cardiol
February 2024
Division of Cardiology, Osaka Rosai Hospital, Sakai, Osaka, Japan.
Article Synopsis
- The study investigates how P-wave morphology affects clinical outcomes and arrhythmia recurrence in patients with paroxysmal atrial fibrillation after undergoing cryoballoon ablation.
- A total of 269 patients were analyzed, focusing on P-wave duration and vector magnitude, with a significant correlation found between higher values and late recurrence of atrial fibrillation (LRAF).
- Results indicated that those with higher P-wave metrics had lower myocardial injury markers and a higher likelihood of developing atrial tachycardia, suggesting the P-wave characteristics can be key predictors in post-ablation outcomes.
Machine learning model for predicting late recurrence of atrial fibrillation after catheter ablation.
Sci Rep
September 2023
"Club 30", Polish Cardiac Society, Warsaw, Poland.
Late recurrence of atrial fibrillation (LRAF) in the first year following catheter ablation is a common and significant clinical problem. Our study aimed to create a machine-learning model for predicting arrhythmic recurrence within the first year since catheter ablation. The study comprised 201 consecutive patients (age: 61.
View Article and Find Full Text PDFRelationship between pre-procedural non-ischemic ST-segment depression and the clinical outcomes after catheter ablation in persistent atrial fibrillation patients.
J Cardiol
May 2023
Division of Cardiology, Osaka Rosai Hospital, Sakai, Osaka, Japan.
Background: ST-segment depression suggests the presence of coronary artery disease (CAD) during sinus rhythm, but the clinical significance, including the outcomes after catheter ablation (CA), in atrial fibrillation (AF) patients remain unknown.
Methods: The present study included persistent AF (PerAF) patients from the Osaka Rosai Atrial Fibrillation ablation (ORAF) registry who underwent an initial ablation and had no history of CAD. We assigned the patients based on the presence of ST-segment depression before CA and evaluated the impact of relevant factors on ST-segment depression and the relationship between ST-segment depression, including leads locations (anterior leads, inferior leads, and lateral leads) or depression type (upsloping, horizontal, and downsloping) or the degree of ST-segment depression and late recurrence of AF (LRAF).
Impact of very early recurrence of atrial fibrillation after cryoballoon ablation.
Pacing Clin Electrophysiol
November 2022
Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan.
Background: Although much has been discussed about the early recurrence of atrial fibrillation (ERAF) after cryoballoon ablation (CBA), the clinical impact of very early recurrence of atrial fibrillation (VERAF) after CBA remains unclear. This study aimed to investigate the impact of VERAF after CBA.
Methods: We enrolled 236 consecutive patients who underwent an initial CBA for paroxysmal atrial fibrillation between February 2017 and December 2020 in our hospital.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!