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Polymorphism in methylentetra-hydrofolate reductase gene: important role in diseases. | LitMetric

Polymorphism in methylentetra-hydrofolate reductase gene: important role in diseases.

Bosn J Basic Med Sci

Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Published: May 2008

AI Article Synopsis

Article Abstract

It has been recognized that some people have a genetic variant which leads to elevated levels of homocysteine and impairs ability to process folate. This condition was recognized as independent risk factor of coronary heart disease. Recently, connection between this termolabile mutation of the methylenetetrahydrofolate reductase and numerous conditions and diseases has been established. Aim of this review is to draw attention to this interesting area in medicine. Additionally, well defined study about presence and frequency of gene polymorphism in our region will provide proper diagnosis and achieve possible delay of development of diseases with vitamin supplementation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698349PMC
http://dx.doi.org/10.17305/bjbms.2008.2975DOI Listing

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