A method has been developed for the methylation of the C3' amide of taxol C and paclitaxel. Taxol C and paclitaxel were sequentially silylated at the 2', 7, and 1-hydroxyl groups with tert-butyldimethylsilyl chloride, triethylsilyl chloride, and dimethylsilyl chloride, respectively. Subsequent reaction with potassium tert-butoxide and methyl iodide provided the corresponding N-methylated taxane derivatives. Removal of the silyl protecting groups furnished N-methyltaxol C and N-methylpaclitaxel.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo800173h | DOI Listing |
Publication Analysis
Top Keywords
c3' amide
8
n-methyltaxol n-methylpaclitaxel
8
taxol paclitaxel
8
n-methylation c3'
4
amide taxanes
4
taxanes synthesis
4
synthesis n-methyltaxol
4
n-methylpaclitaxel method
4
method developed
4
developed methylation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!