The chemopreventive efficacy of cranberry juice concentrate in an experimental model of urinary bladder cancer was evaluated using female Fischer-344 rats. The animals received N-butyl-N-(4-hydroxybutyl)-nitrosamine (OH-BBN) for a period of eight weeks. Cranberry juice concentrate was administered at doses of 1.0 or 0.5 ml/rat/day beginning one week after the final OH-BBN treatment and continuing until the end of the study. The urinary bladders of all the rats were weighed and examined grossly for lesions, and all masses were submitted for pathological evaluation. A dose-dependent preventive effect of cranberry treatment was observed, with a reduced number of urinary bladder cancers (38%) in the 1.0 ml/rat/day group versus the control group. The cranberry extract neither affected body weight gain nor caused other signs of toxicity. For the metabolic studies, serum and urine were collected at 4 and 12 h after the administration of the cranberry juice concentrate and were analyzed by LC-MS/MS. Quercetin and its methylated derivative were detected in the urine samples. However, no quercetin was detected in the serum samples, indicating its poor bioavailability. These data suggest that components of cranberries may be effective in preventing urinary bladder carcinogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709958 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Antibacterial efficacy of berry juices against Bacillus cereus relative to their phytochemical composition and antioxidant properties.
Sci Rep
November 2024
Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 2/22 Bohdana Stefanowskiego, 90-537, Lodz, Poland.
Article Synopsis
- The research focuses on using natural preservatives from berry juices to keep minimally processed foods safe and stable.
- The study tested juices from four berry species against the food pathogen Bacillus cereus, finding that chokeberry had the strongest antibacterial effect, while elderberry showed no inhibition.
- It suggests that the juice's effectiveness is linked to its antioxidant properties rather than just acidity or anthocyanin levels, enhancing our understanding of using berry extracts as biopreservatives.
Effects of Various Solutions on Color Stability and Surface Hardness of Nanohybrid Dental Composite Under Simulated Oral Conditions.
J Contemp Dent Pract
July 2024
Department of Conservative Dentistry and Endodontics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangaluru, Karnataka, India, Phone: +91 9902634770, e-mail:
Aim: This study evaluated effects of various solutions on color stability and surface hardness of a nanohybrid dental composite in simulated oral environments.
Materials And Methods: Sixty-four composite disks were fabricated and randomly allocated into eight groups ( = 8 per group): Artificial saliva (AS), Biotene (B), passion fruit juice (PFJ), orange juice (OJ), Sprite (S), Coca-Cola (CO), apple cider vinegar (ACV), and cranberry juice (CJ). Specimens were immersed in respective solutions at 37°C for 28 days.
Production of Anthocyanin-Enriched Juices by Electrodialysis with Filtration Membrane Process: The Influence of Duration on Juice Composition, Process Efficiency, and Membrane Fouling.
Foods
October 2024
Institute of Nutrition and Functional Foods (INAF), Department of Food Sciences, Université Laval, Quebec, QC G1V OA6, Canada.
The Electrodialysis with Filtration Membrane (EDFM) system has shown promise in juice enrichment, but further optimization is needed. This study evaluated the effect of processing duration (3 and 6 h) on juice composition, process efficiency, and membrane fouling. Results demonstrated a significant impact of processing time on juice composition, especially anthocyanin and mineral content.
View Article and Find Full Text PDFPentacyclic Triterpenoid Content in Cranberry Raw Materials and Products.
Foods
September 2024
Department of Chemistry and Biochemistry and Cranberry Health Research Center, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA.
Cranberry fruit extracts have been shown to inhibit expression of pro-inflammatory cytokines in THP-1 cells and reduce colonic tumor burden and tissue inflammation in a mouse model of colitis. These activities are attributed to both the triterpenoid and polyphenol constituents of the fruit. The pentacyclic triterpenoids ursolic acid (UA), oleanolic acid (OA), corosolic acid (CA), maslinic acid (MA), and esters of UA and OA occur in the waxy layer of cranberry peel, and their content in cranberry products is likely to vary with the fruit source and processing methods.
View Article and Find Full Text PDFA Multiomics Evaluation of the Countermeasure Influence of 4-Week Cranberry Beverage Supplementation on Exercise-Induced Changes in Innate Immunity.
Nutrients
September 2024
College of Computing and Informatics, University of North Carolina at Charlotte, North Carolina Research Campus (NCRC), Kannapolis, NC 28081, USA.
Objectives: This study examined the effect of a 4-week unsweetened cranberry beverage (CRAN) (317 mg polyphenols) versus placebo beverage (PLAC) ingestion (240 mL/day) on moderating exercise-induced changes in innate immunity.
Methods: Participants included 25 male and female non-elite cyclists. A randomized, placebo-controlled, double-blind crossover design was used with two 4-week supplementation periods and a 2-week washout period.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!