Although numbers of prison inmates are increasing rapidly, limited research addresses health-related conditions prevalent in prisons. Compelling reasons exist for prison research to address high rates of psychiatric, neurological, and other health-related conditions that may precipitate or result from incarceration, high-risk behaviors, infectious disease transmission, traumatic brain injuries, and other issues related to incarceration. Prison research is critical because inmates are frequently re-incarcerated and released, posing potential risks to themselves and the community. The purpose of this article is to provide a pragmatic overview of ethical, regulatory, and investigator considerations to facilitate critically needed research with vulnerable prison populations.
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http://dx.doi.org/10.1097/01.ANS.0000319562.84007.22 | DOI Listing |
Eur J Med Res
December 2024
Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Background: The involvement of microRNA-668 (miR-668) in the onset and progression of renal fibrosis remains unclear. To this end, we aimed to explore the relevant mechanism of miR-668 in renal fibrosis.
Methods: C57BL/6 J male mice were randomly divided into sham-operated, unilateral ureteral obstruction (UUO), and UUO-fenofibrate groups.
Harm Reduct J
December 2024
Department of Health Policy and Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Despite Iran's prohibition politics regarding alcoholic beverages consumption, marketing, and trading, there is a flourishing black market. Often, alcohol producers on this black market do not adhere alcohol production standards, resulting in a lot of deaths and significant consequences each year. Accordingly, this study was carried out to identify facilitators for the growth of the black market for alcoholic beverages in Iran and provide solutions for harm reduction.
View Article and Find Full Text PDFBMC Med Educ
December 2024
Department of Orthopedics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, 151203, India.
Generative Artificial Intelligence (AI), characterized by its ability to generate diverse forms of content including text, images, video and audio, has revolutionized many fields, including medical education. Generative AI leverages machine learning to create diverse content, enabling personalized learning, enhancing resource accessibility, and facilitating interactive case studies. This narrative review explores the integration of generative artificial intelligence (AI) into orthopedic education and training, highlighting its potential, current challenges, and future trajectory.
View Article and Find Full Text PDFBMC Microbiol
December 2024
College of Agriculture and Forestry, Linyi University, Linyi, 276005, Shandong, China.
Avian pathogenic Escherichia coli (APEC) is a significant pathogen infecting poultry that is responsible for high mortality, morbidity and severe economic losses to the poultry industry globally, posing a substantial risk to the health of poultry. APEC encounters reactive oxygen species (ROS) during the infection process and thus has evolved antioxidant defense mechanisms to protect against oxidative damage. The imbalance of ROS production and antioxidant defenses is known as oxidative stress, which results in oxidative damage to proteins, lipids and DNA, and even bacterial cell death.
View Article and Find Full Text PDFMol Cancer
December 2024
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Background: Posttranslational modifications (PTMs) play critical roles in hepatocellular carcinoma (HCC). However, the locations of PTM-modified sites across protein secondary structures and regulatory patterns in HCC remain largely uncharacterized.
Methods: Total proteome and nine PTMs (phosphorylation, acetylation, crotonylation, ubiquitination, lactylation, N-glycosylation, succinylation, malonylation, and β-hydroxybutyrylation) in tumor sections and paired normal adjacent tissues derived from 18 HCC patients were systematically profiled by 4D-Label free proteomics analysis combined with PTM-based peptide enrichment.
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