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Background: Granulomatosis with polyangiitis (GPA) is an autoimmune multisystem disorder characterized by small vessel vasculitis with granulomatous inflammation. In this report, we describe a unique case of GPA who presented with complete heart block (CHB) and developed complications due to intracranial large vessel involvement.

Case Summary: A 47-year-old gentleman presented with CHB with a background history of arthralgia and blood-tinged nasal discharge.

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Osseous sarcoidosis is a rare manifestation of sarcoidosis, often mimicking other conditions like metastatic disease. Skeletal involvement occurs in only 3%-13% of cases (1), making diagnosis challenging. We present the case of a 63-year-old female with a 1-month history of inflammatory bone pain and multiple lytic and blastic lesions.

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Article Synopsis
  • Neurosarcoidosis can be difficult to diagnose, especially when there are no other systemic symptoms of sarcoidosis, and it often shows varying clinical presentations.
  • Most cases involve issues like cranial neuropathies or meningitis, making isolated spinal cord involvement rare.
  • This case study discusses a 64-year-old woman with a unique form of neurosarcoidosis presenting as myelopathy due to extra-dural nodules, with pathology confirming the diagnosis and no other neurological or systemic symptoms.
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Mononeuropathy multiplex is a pattern of progressive sensory and motor deficits in the distribution of two or more peripheral nerves. The differential for mononeuropathy multiplex includes vasculitis, autoimmune disorders, infectious diseases, sarcoidosis, amyloidosis, cryoglobulinemia, and paraneoplastic disease. We present a case of a 42-year-old woman with hypothyroidism who presented with 1 week of ascending numbness and weakness, persistent fevers, and 3 months of constant burning pain in both feet.

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Bone sarcoidosis: Extensive hand lesions.

Joint Bone Spine

October 2024

Department of Rheumatology, Avicenne Hospital, 125, rue de Stalingrad, 93000 Paris, France; Inserm U1125, Paris University, Paris, France.

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