AI Article Synopsis
- Dictyostelium discoideum produces a compound known as platelet-activating factor (PAF), which is similar to the PAF found in mammals.
- The activity of PAF increases during starvation and when cells aggregate, but decreases when they reach the slug stage.
- Treatment with cAMP pulses leads to a temporary rise in PAF levels, indicating that PAF may play a role in processes regulated by cAMP in Dictyostelium.
Article Abstract
Evidence is provided that Dictyostelium discoideum cells produce 1-O-alkyl-2-delta-acetyl-O-sn-glycero-3-phosphocholine (platelet-activating factor, PAF). D. discoideum PAF has been characterized as being identical with mammalian platelet-activating factor, based on its stimulation of rabbit platelet aggregation, its physicochemical properties and mass spectrum. The basal activity of PAF increases after starvation and during aggregation and declines at the slug stage. PAF is not detected in the extracellular space. Cell treatment with cAMP pulses stimulates a transient accumulation of PAF, probably via activation of a cAMP-dependent acetyltransferase, suggesting a possible involvement of PAF in cAMP-regulated processes in Dictyostelium.
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| http://dx.doi.org/10.1111/j.1432-1033.1991.tb15856.x | DOI Listing |
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