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Assessment of candidate high-grade serous ovarian carcinoma predisposition genes through integrated germline and tumour sequencing.
NPJ Genom Med
January 2025
Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, only half of which is explained. Previously, we performed germline exome sequencing on BRCA1 and BRCA2-negative HGSOC patients, revealing three proposed and 43 novel candidate genes enriched with rare loss-of-function variants. For validation, we undertook case-control analyses using genomic data from disease-free controls.
View Article and Find Full Text PDFThe use of gold and magnetite-gold composite nanoparticles for the enhanced detection of Salmonella LT2 cells under photoacoustic flow cytometry.
J Colloid Interface Sci
February 2025
Department of Biomedical Engineering, Duquesne University, 600 Forbes Avenue Pittsburgh, Pennsylvania 15282, USA. Electronic address:
Photoacoustic flow cytometry (PAFC) is an emerging technology that has generated significant interest in several research fields, particularly in bacteremia. The application of functionalised nanoparticles like gold and iron oxide-gold complex (FeO-Au) has been realised to enhance the photoacoustic (PA) detection of bacteria cells under PAFC systems. Inclusively, the bacteria cell concentrations are statistically quantified through the number of time-signal detection counts.
View Article and Find Full Text PDFPlasmonic nanoparticle sensors: current progress, challenges, and future prospects.
Nanoscale Horiz
November 2024
CINBIO, Department of Physical Chemistry, Universidade de Vigo, 36310 Vigo, Spain.
Plasmonic nanoparticles (NPs) have played a significant role in the evolution of modern nanoscience and nanotechnology in terms of colloidal synthesis, general understanding of nanocrystal growth mechanisms, and their impact in a wide range of applications. They exhibit strong visible colors due to localized surface plasmon resonance (LSPR) that depends on their size, shape, composition, and the surrounding dielectric environment. Under resonant excitation, the LSPR of plasmonic NPs leads to a strong field enhancement near their surfaces and thus enhances various light-matter interactions.
View Article and Find Full Text PDFBacterial Cellulose as a UVB Filter to Protect the Skin Microbiota.
Macromol Biosci
September 2024
Departamento de Química Inorgánica, Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Av. Fuente nueva, s/n, Granada, 18071, Spain.
Certain aerobic bacteria produce bacterial cellulose (BC) to protect themselves from UV radiation. Inspired by this natural function, the UV-filtering capacity of wet BC film (BC) and dried BC (BC-Dried) is evaluated and it is concluded that both samples hardly filter UVA, but filter UVB to some extent, especially BC-Dried. Moreover, this filtering capacity does not diminish but significantly increases with time, with efficiencies in the 145-160 min time range equal to or greater than most UV filters of the market.
View Article and Find Full Text PDFSilver-based bimetallic nanozyme fabrics with peroxidase-mimic activity for urinary glucose detection.
Anal Bioanal Chem
November 2024
Sir Ian Potter NanoBioSensing Facility, NanoBiotechnology Research Laboratory (NBRL), School of Science, RMIT University, Melbourne, VIC, 3000, Australia.
The enhanced catalytic properties of bimetallic nanoparticles have been extensively investigated. In this study, bimetallic Ag-M (M = Au, Pt, or Pd) cotton fabrics were fabricated using a combination of electroless deposition and galvanic replacement reactions, and improvement in their peroxidase-mimicking catalytic activity compared to that of the parent Ag fabric was studied. The Ag-Pt bimetallic nanozyme fabric, which showed the highest catalytic activity and ability to simultaneously generate hydroxyl (•OH) and superoxide (O) radicals, was assessed as a urine glucose sensor.
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