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Advancing poliovirus eradication: lessons learned from piloting direct molecular detection of polioviruses in high-risk and priority geographies.
Microbiol Spectr
December 2024
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Unlabelled: In the Global Polio Laboratory Network (GPLN), poliovirus (PV) screening results from acute flaccid paralysis (AFP) surveillance is based on virus isolation (VI) through cell culture, entailing long turnaround times and the amplification of live poliovirus. An alternative Direct Detection strategy (DD-ITD) for screening viral nucleic acid from stools, bypassing the need for virus culture, has been developed and extensively validated by GPLN partners. A multi-laboratory demonstration project was conceived to field-test the DD-ITD method by GPLN laboratories from the WHO African, Western Pacific, and Eastern Mediterranean regions, where wild serotype 1 or vaccine-derived polioviruses still circulate.
View Article and Find Full Text PDFThyrotoxic Periodic Paralysis: A Unique Case Highlighting the Diagnostic Challenges and Management.
Cureus
November 2024
Internal Medicine Department, Saint Joseph Hospital, Jerusalem, PSE.
Thyrotoxic periodic paralysis (TPP) is a rare complication primarily associated with thyrotoxicosis, particularly in individuals with Graves' disease. While more common in males aged 20 to 40, it can occur across all ethnic backgrounds. It is the most common type of acquired periodic paralysis.
View Article and Find Full Text PDFSevere Acute Transverse Myelitis With a Rapid Progression in an Infant.
Cureus
October 2024
Pediatric Intensive Care Unit, Hospital Pediátrico, Unidade Local de Saúde de Coimbra, Coimbra, PRT.
Article Synopsis
- Acute transverse myelitis (ATM) is a rare spinal cord inflammation that can result from infections or other systemic diseases, often leading to motor and sensory dysfunction.
- A case report describes a 10-month-old boy with severe ATM likely caused by enteritis, who developed rapid motor deficits and required extended care in a pediatric ICU, including mechanical ventilation.
- Despite various treatments, the patient faced prolonged recovery and significant neurological deficits, underscoring the need for comprehensive care and rehabilitation in managing severe ATM cases.
A case report of porcine circovirus 3 (PCV3) reproductive disease in Iberian semi-outdoor reared sows.
Porcine Health Manag
November 2024
Unitat mixta d'investigació IRTA- UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, 08193, Spain.
Article Synopsis
- Porcine circovirus 3 (PCV3) is a newly identified pathogen linked to reproductive issues in pigs, notably in intensive farming setups.
- A case study from a semi-outdoor Iberian sow farm highlighted significant reproductive disease symptoms, including a rise in mummified fetuses and stillborn piglets primarily among gilts, while multiparous sows remained unaffected.
- Investigations confirmed the presence of PCV3 through tissue analysis, displaying specific lesions such as lymphohistiocytic myocarditis, marking the first documented incidence of PCV3 reproductive disease in this farming system.
[Acute internal carotid artery occlusion following administration of Andexanet alfa for the reversal of direct factor Xa inhibitors in patients with cerebral hemorrhage].
Rinsho Shinkeigaku
October 2024
Department of Neurology, Kobe City Medical Center General Hospital.
Article Synopsis
- - An 87-year-old woman with a history of stroke and pulmonary embolism developed aphasia and right hemiplegia, leading to a hospital visit where a CT scan revealed a hematoma in her left thalamus.
- - After administering low-dose Andexanet alfa shortly after the onset of her stroke, her condition worsened to flaccid hemiplegia and coma, and further imaging showed occlusion of her left internal carotid artery.
- - Despite mechanical thrombectomy attempts, she suffered extensive cerebral infarction and died on day 7, underscoring that thrombotic events can occur even after Andexanet alfa treatment, necessitating careful monitoring of patients.
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