Comprehensive study of brain performances implies reference to sequences of repetitive functional elements (events). In this particular experimental field, these are sequences of psychomotor reactions and particularly verbal reactions with different modalities of stimuli and pre-established intervals before responding. The organization of these sequences or temporal cycles is based on different sets of stimuli and series of processes that are measured through parameters related to trials that activate the central mechanism of working memory. Monitoring of sequences in rehabilitation training is performed through analysis of the course of the intermediary oscillations between the onset and the end (conventionally established) of treatment. Knowledge of these oscillations provides useful information on the nature of facilitating or fatiguing effects of training procedures.
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Autism Res
January 2025
Center for Medical Genetics and Hunan key Laboratory of Medical Genetics, MOE Key Laboratory of Rare Pediatric Disease, School of Life Sciences, Central South University, Changsha, Hunan, China.
Neurodevelopmental disorders (NDDs) encompass a group of conditions that impact brain development and function, exhibiting significant genetic and clinical heterogeneity. NAA15, the auxiliary subunit of the N-terminal acetyltransferase complex, has garnered attention due to its association with NDDs. However, the precise role of NAA15 in cortical development and its contribution to NDDs remain elusive.
View Article and Find Full Text PDFJ Therm Biol
January 2025
ASSET, INRAE, Petit-Bourg (Guadeloupe), 97170, France.
Estimating animal behaviour during heat stress (HS) is particularly insightful to monitor animal welfare but also to better understand how animals thermoregulate. The present study is a proof of concept combining computer vision to monitor animal behaviour, continuous monitoring of subcutaneous temperature and recording of ambient temperature, with the aim to study the link between behaviour and animal body temperature during HS. A total of 22 pigs were video-monitored from 8:00 to 18.
View Article and Find Full Text PDFCell Rep
January 2025
Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:
Here, we used single cell RNA sequencing and single cell spatial transcriptomics to characterize the forebrain neural stem cell (NSC) niche under homeostatic and injury conditions. We defined the dorsal and lateral ventricular-subventricular zones (V-SVZs) as two distinct neighborhoods and showed that, after white matter injury, NSCs are activated to make oligodendrocytes dorsally for remyelination. This activation is coincident with an increase in transcriptionally distinct microglia in the dorsal V-SVZ niche.
View Article and Find Full Text PDFPeerJ
January 2025
School of Mathematics and Computer Science, Gannan Normal University, Ganzhou, China.
Background: Convolutional neural networks have excellent modeling abilities to complex large-scale datasets and have been applied to genomics. It requires converting genotype data to image format when employing convolutional neural networks to genome-wide association studies. Existing studies converting the data into grayscale images have shown promising.
View Article and Find Full Text PDFNonlinear Dyn
September 2024
Department of Mathematics, University College London, London, UK.
Time series is a data structure prevalent in a wide range of fields such as healthcare, finance and meteorology. It goes without saying that analyzing time series data holds the key to gaining insight into our day-to-day observations. Among the vast spectrum of time series analysis, time series classification offers the unique opportunity to classify the sequences into their respective categories for the sake of automated detection.
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