AI Article Synopsis
- A new method for producing (R)-H 4-BINOL, which is important for asymmetric catalysis, is presented.
- The process effectively scales to produce larger amounts (gram scale) of this compound.
- The main breakthrough involves partially hydrogenating (R)-BINOL after first modifying it through a bis-etherification step.
Article Abstract
A method amenable to the gram scale synthesis of (R)-H 4-BINOL, a derivative of (R)-BINOL and ligand of interest in asymmetric catalysis, is described. The key step is the net partial hydrogenation of (R)-BINOL made possible by prior bis-etherification of the parent BINOL.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587137 | PMC |
| http://dx.doi.org/10.1021/jo8004556 | DOI Listing |
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