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Disseminated Cryptococcal Gattii infection in a patient with anti-granulocyte-macrophage colony-stimulating-factor autoantibody: a case report.
BMC Infect Dis
December 2024
Division of Cardiovascular Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Background: Cryptococcosis is an opportunistic fungal infection in immunocompromised patients. The major species include Cryptococcus grubii, Cryptococcus neoformans, and rarely, Cryptococcus gattii. Here we present a disseminated Cryptococcus gattii infection in a patient with elevated granulocyte-macrophage colony-stimulating-factor autoantibody which was successfully treated with antifungal therapy.
View Article and Find Full Text PDFUnlabelled: is a fungal pathogen that can cause lethal disease in immunocompromised patients. Immunocompetent host immune responses, such as formation of pulmonary granulomas, control the infection and prevent disseminated disease. Little is known about the immunological conditions establishing the latent infection granuloma in the lungs.
View Article and Find Full Text PDFMultiple Central Nervous System Cryptococcomas Masquerading as Lymphoma.
Neurohospitalist
December 2024
Department of Neurology, TriStar Centennial Medical Center, Nashville, TN, USA.
Cryptococcal meningitis is a leading cause of morbidity and mortality in patients infected with human immunodeficiency virus. In over 90% of cases, it occurs at CD4 T lymphocyte (CD4) cell counts of less than 100 cells/mm. Cryptococcomas are rare granulomatous lesions that can occur in disseminated central nervous system cryptococcal infection, primarily in immunocompetent hosts.
View Article and Find Full Text PDFIL-22 and IL-23 regulate the anticryptococcal response during infection.
iScience
October 2024
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-900, Brazil.
Article Synopsis
- Cryptococcosis, caused by environmental fungi, leads to severe pneumonia and systemic infections, especially in immune-compromised individuals, with rising cases seen in immunocompetent hosts due to strain R265.* -
- The study investigates the roles of cytokines IL-22 and IL-23 in managing lung health during R265 infections, revealing their importance in preserving lung barrier integrity and preventing excessive damage.* -
- Findings indicate that IL-22 helps control neutrophil activity and promotes eosinophil presence in the lungs, providing crucial insights into immune response and tissue management during aggressive cryptococcal infections.*
Primary cutaneous cryptococcosis - History, concepts, clinical and therapeutic update.
An Bras Dermatol
November 2024
Department of Infectology, Dermatology, Diagnostic Imaging and Radiotherapy, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Cryptococcosis is a disease caused by fungi of the genus Cryptococcus, with the species Cryptococcus neoformans and Cryptococcus gattii being recognized as pathogenic. Cutaneous cryptococcosis can be classified as "secondary", developing from a previous systemic disease, or, on the contrary, "primary", resulting from transcutaneous inoculation of the agent. It can also be classified as "disseminated cutaneous cryptococcosis", when there is an associated systemic disease, or "localized", when it is restricted to the skin.
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