In order to select bacteriocin producing strains the screening of microorganisms from clinical material was perfomed. The delayed antagonism method was used. 154 strains were screened, 93 (60%) cultures produced antagonistic substances. Micrococcus luteus NCTC, 2665, Candida albicans ATCC 885-653, Escherichihia coli 168/59, Pseudomonas aeruginosa 27/99, Klebsiella peumoniae 1954 were used as test-cultures, Pseudomonas aenruginosa and Staphylococcys aureus were the most frequent species producing antibacterial substances and their products were of high potency, with a wide spectrum of antimicrobial activity.

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