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Presentation and surgical management approaches of giant presacral and sacral schwannomas: a case report and systematic review and meta-analysis.
Eur Spine J
January 2025
Department of Neurosurgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Background: Giant sacral and presacral schwannomas are very rare conditions and their prevalence is estimated to account for only 0.3 to 3.3% of overall schwannomas.
View Article and Find Full Text PDFA Single-Institution Analysis of Surveillance Practice for Low-Risk Neuroblastic Tumors.
J Surg Res
January 2025
Division of Pediatric Surgery, Nationwide Children's Hospital, Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio. Electronic address:
Introduction: Currently, few prospective guidelines exist for the surveillance of children with low-risk neuroblastic tumors (LRNBTs), including ganglioneuroma or ganglioneuroblastoma intermixed. This study aims to describe our institutional approach to LRNBT surveillance following surgical resection or nonoperative management. We hypothesize that length of surveillance can be reduced due to low recurrence risk.
View Article and Find Full Text PDF[Chinese expert consensus on standardized treatment of presacral cyst (2024 edition)].
Zhonghua Zhong Liu Za Zhi
January 2025
Article Synopsis
- Surgical excision is the main treatment for presacral cysts, but it's challenging due to nearby blood vessels and nerves, which can lead to complications and recurrence if done incorrectly.
- The Chinese Expert Consensus on the Standardized Diagnosis and Treatment of Presacral Cysts (2024 edition) was developed by a team of specialists to address these challenges and improve patient outcomes.
- Key updates in the 2024 consensus include new classifications for cyst anatomy, a focus on protecting sacral nerves during surgery, and clearer surgical approaches for different types of cysts.
Spontaneous Intracranial Hypotension and Dural Ectasia in Marfan Syndrome: An Illustrative Case Successfully Treated with Steroid Therapy and Literature Review.
Brain Sci
November 2024
Institute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168 Roma, Italy.
Article Synopsis
- Spontaneous intracranial hypotension (SIH) is a rare condition often misdiagnosed, particularly in patients with connective tissue disorders like Marfan Syndrome, which can lead to structural weaknesses in the spinal dural membrane and increased risk of CSF leaks.
- A 52-year-old woman with genetically confirmed Marfan Syndrome presented with severe headaches and diplopia; imaging revealed complications such as dural ectasia and subdural hematoma, which were effectively managed with bed rest and corticosteroids.
- A review of 25 studies on SIH treatment in patients with Marfan Syndrome indicated high success rates for symptoms improvement, particularly with epidural blood patches and conservative treatments.
Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer.
N Engl J Med
October 2024
From Baylor College of Medicine (S.P.L.) and the University of Texas M.D. Anderson Cancer Center (A.M.K.), Houston, the University of Texas Health San Antonio (R.S.S.) and CHRISTUS Santa Rosa Medical Center Hospital (I.M.T.), San Antonio, and the University of Texas Southwestern Medical Center, Dallas (A.I.S.) - all in Texas; Stanford University, Stanford (E.S.), Norris Comprehensive Cancer Center, University of Southern California, Los Angeles (S.D., A.S.), and City of Hope Medical Center, Duarte (S.K.P.) - all in California; SWOG Statistics and Data Management Center and Fred Hutchinson Cancer Center - both in Seattle (C.T., M.P.); the Ohio State University, Columbus (K.S.P.); the University of Chicago, Chicago (N.D.S.); McGill University Health Center, Montreal (W.K.); the Bladder Cancer Advocacy Network, SWOG Advocates, Pittsford, NY (R.B.); Oregon Health and Science University, Portland (T.M.K.); the University of Michigan, Ann Arbor (A.A.); the University of Colorado, Aurora (F.G.L.R.); Brigham and Women's Hospital, Boston (A.S.K.); Fox Chase Cancer Center, Philadelphia (D.J.C.); and Oschsner Medical Center, Jefferson, LA (D.J.C.).
Background: Whether extended lymphadenectomy is associated with improved disease-free and overall survival, as compared with standard lymphadenectomy, among patients with localized muscle-invasive bladder cancer undergoing radical cystectomy is unclear.
Methods: We randomly assigned, in a 1:1 ratio, patients with localized muscle-invasive bladder cancer of clinical stage T2 (confined to muscle) to T4a (invading adjacent organs) with two or fewer positive nodes (N0, N1, or N2) to undergo bilateral standard lymphadenectomy (dissection of lymph nodes on both sides of the pelvis) or extended lymphadenectomy involving removal of common iliac, presciatic, and presacral nodes. Randomization was performed during surgery and stratified according to the receipt and type of neoadjuvant chemotherapy, tumor stage (T2 vs.
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