Population data and mutation rate of nine Y-STRs in a mestizo Mexican population from Guadalajara, Jalisco, México.

Jorge Ramón Padilla-Gutiérrez Yeminia Valle Antonio Quintero-Ramos Guillermo Hernández Katya Rodarte Rocío Ortiz Norma Olivares Fernando Rivas

Leg Med (Tokyo)

Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Colonia Independencia, Guadalajara, Jalisco 44340, Mexico.

Published: November 2008

* A family study involving 200 father/son pairs identified five single-step mutations among 1828 meiosis events.
* The overall mutation rate for the Y-STRs was estimated at 2.7 x 10(-3) per locus per meiosis, suggesting these markers are valuable for forensic purposes.

Nine Y-STR (DYS19, DYS390, DYS391, DYS392, DYS446, DYS447, DYS448, DYS456 and DYS458) were analyzed in a male sample of 285 unrelated individuals from Guadalajara, Jalisco, México. The haplotype diversity (0.996) and discrimination capacity (0.986) were calculated. A family study of around 200 father/son pairs and among 1828 meiosis showed five mutational events. All mutations were single step. The overall mutation rate estimated across the nine Y-STRs was 2.7 x 10(-3) (95% CI 1.2-6.4 x 10(-3))/locus/meiosis. The results indicate that these nine loci are useful Y-linked markers for forensic applications.

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http://dx.doi.org/10.1016/j.legalmed.2008.03.004	DOI Listing

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