Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2008.04.075 | DOI Listing |
Publication Analysis
Top Keywords
potent dpp-4
8
dpp-4 inhibitors
8
35-dihydro-imidazo[45-d]pyridazin-4-ones class
4
class potent
4
inhibitors systematic
4
systematic variations
4
variations xanthine
4
xanthine scaffold
4
scaffold close
4
close analogs
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!