AI Article Synopsis
- Zinc deficiency in male rats leads to reduced body growth and lower organ weights, particularly in the prostate.
- A low-zinc diet also causes decreases in hematopoiesis, hypo-albuminemia, and lower testosterone and luteinizing hormone levels.
- The study indicates that zinc plays a crucial role in prostate health by affecting DNA replication and key enzyme expression related to cell metabolism.
Article Abstract
Background: Zinc has a wide spectrum of biological activities and its deficiency is related to various abnormalities of cell metabolism.
Methods: Wistar male rats, at age of 4 weeks, were fed a low-zinc diet for six weeks. The levels of bromodeoxyuridine incorporated into the prostatic DNA and the mRNA expression levels of prostate thymidylate synthase and thymidine kinase were examined.
Result: The low-zinc diet caused a marked reduction in the body growth and organ weights, resulted in a low hematopoiesis, hypo-albuminemia and hypocholesterolemia. Although there were few differences in plasma biochemical markers, plasma levels of luteinizing hormone and testosterone were reduced by the low-zinc diet. Bromodeoxyuridine-immunoreactive (S-phase) cells and mRNA expression levels of thymidylate synthase and thymidine kinase in the prostate cells were markedly affected by the low-zinc diet.
Conclusion: A low-zinc diet appears to reduce the body growth and organ weights including prostate, causing low plasma levels of luteinizing hormone and testosterone and reduction in prostate DNA replication in growing-rats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397411 | PMC |
| http://dx.doi.org/10.1186/1743-7075-5-12 | DOI Listing |
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