In the optic flow illusion, the focus of an expanding optic flow field appears shifted when uniform flow is transparently superimposed. The shift is in the direction of the uniform flow, or "inducer." Current explanations relate the transformation of the expanding optic flow field to perceptual subtraction of the inducer signal. Alternatively, the shift might result from motion capture acting on the perceived focus position. To test this alternative, we replaced expanding target flow with contracting or rotating flow. Current explanations predict focus shifts in expanding and contracting flows that are opposite but of equal magnitude and parallel to the inducer. In rotary flow, the current explanations predict shifts that are perpendicular to the inducer. In contrast, we report larger shift for expansion than for contraction and a component of shift parallel to the inducer for rotary flow. The magnitude of this novel component of shift depended on the target flow speed, the inducer flow speed, and the presentation duration. These results support the idea that motion capture contributes substantially to the optic flow illusion.
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http://dx.doi.org/10.1167/8.4.27 | DOI Listing |
Cancer Genomics Proteomics
December 2024
Department of Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea
Background/aim: Replication factor C subunit 3 (RFC3) is a critical component of the replication factor C complex, which is essential for DNA replication and repair. Recent studies have highlighted the RFC3's significance in various cancer types. Herein, we aimed to elucidate its biological role in cervical cancer.
View Article and Find Full Text PDFMult Scler Relat Disord
December 2024
Istanbul University, Aziz Sancar Institute for Experimental Medical Research, Department of Neuroscience, Istanbul, Turkiye.
Objective: Multiple sclerosis (MS) may present with predominant involvement of the spinal cord and optic nerve (MS/w-SCON) and mimic other autoimmune inflammatory demyelinating disorders (AIDD) such as neuromyelitis optica spectrum disorder (NMOSD), and relapsing inflammatory optic neuritis (RION). Thus, biomarkers are required for effective differential diagnosis of AIDD.
Methods: Patients with MS/w-SCON (n = 20), MS without involvement of SCON (MS/wo-SCON) (n = 22), NMOSD (n = 16), RION (n = 15) and healthy individuals (n = 21) were included.
Ophthalmol Ther
December 2024
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.
Introduction: This study aims to summarize the retinal and choroidal microvascular features detected by optical coherence tomography angiography (OCTA) in the affected and fellow eyes of patients with retinal vein occlusion (RVO).
Methods: A comprehensive search of the PubMed, Embase, and Ovid databases was conducted to identify studies comparing OCTA metrics among RVO, RVO-fellow, and control eyes. Outcomes of interest included parameters related to foveal avascular zone (FAZ) and fovea- and optic nerve head (ONH)-centered perfusion measurements of superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris layer.
Radiother Oncol
December 2024
Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, 1090 Brussels, Belgium. Electronic address:
Background And Purpose: Tumor hypoxia is the principal cause of clinical radioresistance. Despite its established role as radiosensitizer, hydrogen peroxide (HO) encounters clinical limitations due to stability and toxicity concerns. Recent advancements in drug delivery combine HO with sodium hyaluronate (SH), enabling intratumoral administration of HO.
View Article and Find Full Text PDFExp Eye Res
December 2024
Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, WI, 53226, USA; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, WI, 53226, USA. Electronic address:
Genome or prime editing has become a promising tool for the treatment of hereditary disorders affecting the inner retina, such as dominant optic neuropathies. In vivo delivery of gene editors, such as Cas9, is typically achieved using recombinant adeno-associated virus (rAAV) vectors, which have a broad range of cellular tropisms and are well tolerated following intravitreal administration. Owing to the large size of gene editing constructs and the limited carrying capacity of rAAV (<5.
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