Introduction: Given that we have reached a point in the field of muscle energetics where absolute measurements are warranted to take the area forward, we designed an ergometer, including two force and two displacement transducers, allowing dynamic and isometric knee extension within a MR system and accurate measurements of power output.
Methods: On the basis of repeated measurements, the force and displacement transducers accuracy was 1% for values ranging from 0 to 394 N and 4% for values ranging from 0 to 20 cm. In addition, measurements were not affected by magnetic field. MRS experiments in exercising muscle were conducted in eight subjects. They performed two standardized dynamic alternate leg extension exercises (25 and 35% of MVC) while the corresponding metabolic changes were measured using (31)P-MRS.
Results: The mean power output produced during both exercises were 63 +/- 16 and 81 +/- 15 W while the eccentric work was reduced i.e. 12 +/- 14 and 21 +/- 6 W for the moderate and heavy exercise respectively. The corresponding metabolic changes were significant with a 20-40% PCr depletion and an end of exercise pH ranging from 0.02 to 0.70 pH units.
Conclusion: Overall, the present ergometer allows quadriceps exercise in a MR system and should be useful for future metabolic studies for which reliable and absolute quantification of power output is warranted.
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