Background: Stratum corneum composition and structure limit cutaneous bioavailability of pharmaceutical and cosmetical agents. Electrically assisted transport can increase the rate and extent of delivery; moreover, it also enables the administration of polar and charged molecules into the skin.
Aims: The objective of this study was to investigate the effect of electrotreatment on skin permeability by measuring the cumulative delivery of caffeine and sodium ascorbyl phosphate. Furthermore, confocal microscopy was used to visualize the effect of electrotreatment on the penetration of calcein.
Methods: Porcine ear skin was used for the in vitro permeation studies, which involved application of either the caffeine or sodium ascorbyl phosphate (NAP) containing gels using the roll-on supplied with the electrotreatment device.
Results: Electrotreatment increased the amount of caffeine and NAP in the skin. Enhancement factors (EF) for NAP of 7.2 and 14.9 were observed following 20 min of electrotreatment and either immediate sampling or a further 60 min of passive diffusion compared with passive diffusion for either 20 or 80 min. The effect on caffeine permeation was less significant (EF = 2.1 for 20 min electrotreatment compared with passive diffusion for 20 min). The confocal microscopy images showed that electrotreatment significantly increased calcein permeation; fluorescence was observed deep into the viable epidermis-reaching depths of up to 60 to 80 microns.
Conclusions: We have shown that electrotreatment increases skin permeability and the cumulative delivery of cosmeticals into the skin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1473-2165.2008.00372.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Skin disease-associated GJB4 variants differentially influence connexin stability, cell viability and channel function.
J Physiol
January 2025
Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.
Here we characterize seven Cx30.3 gene variants (R22H, S26Y, P61R, C86S, E99K, T130M and M190L) clinically associated with the rare skin disorder erythrokeratodermia variabilis et progressiva (EKVP) in tissue-relevant and differentiation-competent rat epidermal keratinocytes (REKs). We found that all variants, when expressed alone or together with wildtype (WT) Cx30.
View Article and Find Full Text PDFThe TRP Channels Serving as Chemical-to-Electrical Signal Converter.
Physiol Rev
January 2025
Department of Physiology and Membrane Biology, University of California, Davis, School of Medicine, Davis CA, 95616, USA.
Biology uses many signaling mechanisms. Among them, calcium and membrane potential are two prominent mediators for cellular signaling. TRPM4 and TRPM5, two calcium-activated monovalent cation-conducting ion channels, offer a direct linkage between these two signals.
View Article and Find Full Text PDFThe Role and Implications of Epidermal Dysfunction in the Pathogenesis of Inflammaging.
J Invest Dermatol
January 2025
Dermatology Hospital of Southern Medical University, Guangzhou, China. Electronic address:
Inflammaging has long been linked to the pathogenesis of various aging-associated disorders, including cardiovascular disease, obesity, type 2 diabetes, and dementia. Yet, the origins of inflammaging remain unclear. Although inflammatory dermatoses such as psoriasis and atopic dermatitis predispose to the development of certain aging-associated disorders, suggesting a pathogenic role of cutaneous inflammation in these disorders, the great majority of aged humans do not have inflammatory dermatoses.
View Article and Find Full Text PDF[Research progress in acupoint administration of new dosage forms of traditional Chinese medicine preparations for rheumatoid arthritis].
Zhongguo Zhong Yao Za Zhi
December 2024
College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine Guiyang 550025, China National Engineering Technology Research Center for Miao Medicine Guiyang 550025, China Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine Guiyang 550025, China.
The conventional acupoint therapy for rheumatoid arthritis often uses traditional Chinese medicine preparations in the dosage forms of powder, ointment, and paste. However, these dosage forms have obvious drawbacks, such as low transdermal absorption, strong skin irritation, and easy detachment. Creating a traditional Chinese medicine acupoint therapy characterized by high penetration, low toxicity, low irritation, and convenient administration is of great significance.
View Article and Find Full Text PDFNatural phenylethanoid glycoside forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice.
Eur J Pharmacol
January 2025
Department of Pharmacology, School of Pharmacy, Qingdao Medical College of Qingdao University, Qingdao, China; Institute of Innovative Drugs, Qingdao University, Qingdao, China.
Dihydrotestosterone (DHT), an androgen derivate, is known to be a key factor involved in androgenetic alopecia. DHT suppresses the growth of outer root sheath cells and induces apoptosis of hair keratinocytes, thereby causing hair follicle miniaturization and hair regrowth inhibition. Forsythoside A, a natural substance derived from Forsythia suspensa, has been shown to reduce DHT-induced apoptosis in human hair cells and suppress hair regrowth inhibition induced by DHT in mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!