To probe into the relation between spirit, pivot and the way for holding pivot. Find out the discussion about spirit, pivot and holding pivot in acupuncture from ancient books, including literature, history and philosophy, and analyze, check and compare with the theory of controlling spirit in acupuncture, and find out the internal relations. Controlling spirit is applied to hold pivot, the way for holding pivot includes finding fine evidence of diseases, holding chance for needling, seizing opportunity, using circumstances and considering the coming-and-going of evil, constitution of patients and reinforcing-reducing methods of acupuncture. The way of holding pivot generalizes the main thought of acupuncture treatment.
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The advancement of economical and readily available electrocatalysts for the oxygen reduction reaction (ORR) holds paramount importance in the advancement of fuel cells and metal-air batteries. Recently, 2D non-metallic materials have obtained substantial attention as viable alternatives for ORR catalysts due to their manifold advantages, encompassing low cost, ample availability, substantial surface-to-volume ratio, high conductivity, exceptional durability, and competitive activity. The augmented ORR performances observed in metal-free 2D materials typically arise from heteroatom doping, defects, or the formation of heterostructures.
View Article and Find Full Text PDFChild Abuse Negl
August 2024
Georgia State University, School of Public Health, United States of America.
Background: Evidence-based prevention services for child abuse and neglect (CAN), typically delivered via home visiting (HV), pivoted to virtual delivery in 2020 to continue family services while adhering to the COVID-19 public health guidelines.
Objective: The study aims are to compare parent and implementation outcomes for the HV program, SafeCare©, delivered virtually versus in-person, across a 2-year period.
Methods: Three data sources were used to examine parent program engagement and skill mastery, as well as provider fidelity.
NPJ Precis Oncol
July 2024
Université Paris Cité, Dermato-Oncology and CIC AP-HP Hôpital Saint Louis, Cancer Institute APHP, Nord-Université Paris Cité, Paris, France.
In PIVOT IO 001 (NCT03635983), the combination of the investigational interleukin-2 agonist bempegaldesleukin (BEMPEG) with nivolumab (NIVO) had no added clinical benefit over NIVO monotherapy in unresectable/metastatic melanoma. Pre-defined baseline and on-treatment changes in selected biomarkers were analyzed to explore the potential mechanisms underlying the clinical observations. In each treatment arm, higher baseline tumor mutational burden or immune infiltration/inflammation was associated with improved efficacy compared with lower levels.
View Article and Find Full Text PDFArtif Organs
November 2024
Medical Imaging and Image Processing Research Group, Center for Informatics Science, Nile University, Sheikh Zayed City, Egypt.
Background: Retinal prostheses offer hope for individuals with degenerative retinal diseases by stimulating the remaining retinal cells to partially restore their vision. This review delves into the current advancements in retinal prosthesis technology, with a special emphasis on the pivotal role that image processing and machine learning techniques play in this evolution.
Methods: We provide a comprehensive analysis of the existing implantable devices and optogenetic strategies, delineating their advantages, limitations, and challenges in addressing complex visual tasks.
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