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Exploring the neural mechanisms linking healthy aging and cognitive maintenance: insights from Mendelian randomization and mediation analyses.
Cereb Cortex
March 2025
Department of Radiology, Fifth People's Hospital of Shanghai, Fudan University, 801 Heqing Road, Minhang District, Shanghai 200240, China.
As global population ages, maintaining cognitive health in elderly is crucial. Previous studies suggest a positive link between healthy aging and cognition, but the neural mechanisms remain unclear. This study used genome-wide association studydata to investigate neural mechanisms between healthy aging and cognition.
View Article and Find Full Text PDFChild Vocabulary and Developmental Growth in Executive Functions During Toddlerhood.
Dev Sci
May 2025
Department of Psychology, Université de Montréal, Montréal, Québec, Canada.
Executive functions (EFs) emerge in the first years of life and are essential for many areas of child development. However, intraindividual developmental trajectories of EF during toddlerhood and their associations with ongoing development of language skills remain poorly understood. The present three-wave study examined these trajectories and their associations with language skills.
View Article and Find Full Text PDFEfficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors.
Pak J Pharm Sci
March 2025
Department of Cardiology, the Third Affiliated Hospital of Qiqihar Medical College, China.
To evaluate the comparative efficacy of Ticagrelor and Clopidogrel in treating patients with coronary heart disease and unstable angina, as well as their effects on serum inflammatory factors, thereby providing a solid foundation for future clinical diagnosis and treatment. The frequency of angina attacks in the Ticagrelor group was lower than in the Clopidogrel group (P<0.05).
View Article and Find Full Text PDFComparative study on the drug effects and adverse reactions of doxycycline and isotretinoin in the treatment of moderate to severe acne.
Pak J Pharm Sci
March 2025
Department of Plastic and Cosmetic Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
To compare the drug effects and adverse reactions of doxycycline and isotretinoin in patients with moderate to severe acne. A retrospective analysis was conducted on 98 patients with moderate to severe acne who were treated in the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from June 2020 to June 2023. They were divided into group A and group B based on actual medication use, with 49 cases in each group.
View Article and Find Full Text PDFEfficacy analysis of vincristine, adriamycin, dexamethasone chemotherapy regimen combined with thalidomide in the treatment of multiple myeloma nephropathy and its impact on renal function factors.
Pak J Pharm Sci
March 2025
Department of Nephrology, People's Hospital of Shangrao City, Shangrao, Jiangxi Province, China.
Myeloma nephropathy is a rare but challenging disease. This study aimed to evaluate the efficacy and renal functional outcomes of the VAD chemotherapy regimen and thalidomide treatment for myeloma nephropathy. From August 2022 to December 2023, a total of 94 patients were admitted to People's Hospital of Shangrao City.
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