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Complete skin remission of Sneddon-Wilkinson disease with acalabrutinib.
Australas J Dermatol
November 2024
Sir Peter McCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Sneddon-Wilkinson (SW) disease is rare condition which typically occurs in the context of a monoclonal immunoglobulin and treatment options have not been well studied. Here we present a case of a 65-year-old female with SW with underlying, otherwise indolent, lymphoplasmacytic lymphoma (LPL) with an IgA paraprotein, who achieved a complete skin remission with the administration of the Bruton Tyrosine Kinase inhibitor (BTKi), acalabrutinib.
View Article and Find Full Text PDFTwo cases of eosinophilic pustular folliculitis successfully treated with abrocitinib.
J Dermatol
December 2024
Dermatology Hospital of Southern Medical University, Guangzhou, China.
Article Synopsis
- Eosinophilic pustular folliculitis (EPF) is a rare inflammatory skin disease mainly involving eosinophils and can appear in both follicle areas and less commonly in follicle-free areas.
- This case study details two patients with difficult-to-treat EPF who had previous treatment failures with various standard therapies.
- Both patients responded positively to the medication abrocitinib, achieving complete remission in one week and four weeks, with no side effects reported, suggesting it could be a safe treatment option for EPF.
Paradoxical reaction to IL-17A inhibitor: a case report and literature review.
Front Med (Lausanne)
April 2024
Department of Dermatology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Objective: A case of pustular psoriasis after treatment with secukinumab in a patient with plaque psoriasis is reported, which is the first case in China. To summarize the clinical characteristics of patients who developed the rare paradoxical reaction and treatment options received IL-17A antagonist therapy, we conducted a further literature review.
Methods: Data were analyzed from a patient with plaque psoriasis who developed pustular psoriasis after treatment with secukinumab.
The parapoxvirus Orf virus inhibits dsDNA-mediated type I IFN expression via STING-dependent and STING-independent signalling pathways.
J Gen Virol
October 2023
Virus Research Unit, Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Type I interferons (IFNs) are critical in the host defence against viruses. They induce hundreds of interferon-stimulated genes (ISGs) many of which have an antiviral role. Poxviruses induce IFNs via their pathogen-associated molecular patterns, in particular, their genomic DNA.
View Article and Find Full Text PDFTofacitinib Versus Oral Prednisolone for Induction of Remission in Moderately Active Ulcerative Colitis [ORCHID]: A Prospective, Open-Label, Randomized, Pilot Study.
J Crohns Colitis
February 2024
Department of Gastroenterology, Dayanand Medical College, Ludhiana, Punjab, 141001, India.
Background: Oral corticosteroids are first-line agents to induce remission in moderately active ulcerative colitis [UC], but are associated with adverse effects. We compared the efficacy and safety of tofacitinib and prednisolone for induction of remission in moderately active UC.
Methods: This was a single-centre, prospective, open-label, randomized, active-controlled pilot study.
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