Defined candidate human vaccines for treating infection by Yersinia pestis, the agent of plague, have been developed. To facilitate evaluation of the vaccines' efficacy, the in vitro caspase-3 assay for cytotoxicity-neutralizing activity was modified and reevaluated. Immune serum-mediated caspase-3 neutralizing activity correlated with protection against infection in a nonhuman primate vaccine model of plague immunity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446635 | PMC |
| http://dx.doi.org/10.1128/CVI.00091-08 | DOI Listing |
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