Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1751-553X.2007.00945.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The unanticipated contribution of Zap70 in retinal degeneration: Implications for microglial inflammatory activation.
Prog Neurobiol
January 2025
Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea. Electronic address:
Inflammation is a major mechanism of photoreceptor cell death in the retina during macular degeneration leading to the blindness. In this study, we investigated the role of the kinase molecule Zap70, which is an inflammatory regulator of the systemic immune system, to elucidate the control mechanism of inflammation in the retina. We observed activated microglial cells migrated and populated the retinal layer following blue LED-induced photoreceptor degeneration and activated microglial cells in the LED-injured retina expressed Zap70, unlike the inactive microglial cells in the normal retina.
View Article and Find Full Text PDFMathematical multi-compartment modeling of chronic lymphocytic leukemia cell kinetics under ibrutinib.
iScience
December 2024
Institute of AI for Health, Helmholtz Munich - German Research Centre for Environmental Health, Neuherberg, Germany.
The Bruton tyrosine kinase inhibitor ibrutinib is an effective treatment for patients with chronic lymphocytic leukemia (CLL). While it rapidly reduces lymph node and spleen size, it initially increases the number of lymphocytes in the blood due to cell redistribution. A previously published mathematical model described and quantified those cell kinetics.
View Article and Find Full Text PDFEndogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.
J Clin Invest
November 2024
Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine.
Article Synopsis
- - The study investigates how impaired signaling in naïve CD4+ T cells leads to the development of pathogenic autoreactive cells, which play a role in autoimmune arthritis, specifically using SKG mice with a mutated Zap70 gene.
- - Researchers found these pathogenic T cells had increased expression of activation and cytokine-related genes, but reduced expression of markers that usually promote tolerance compared to healthy cells.
- - The presence of specific TCR variable beta chains linked to superantigens from mouse retroviruses suggests that these viral elements may disrupt normal immune tolerance, fostering the development of self-reactive CD4+ T cells into harmful effector cells, with potential therapeutic implications.
Intrinsic ADRB2 inhibition improves CAR-T cell therapy efficacy against prostate cancer.
Mol Ther
October 2024
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China. Electronic address:
Chimeric antigen receptor (CAR)-T cell therapy has shown limited success in patients with solid tumors. Recent in vitro and in vivo data have shown that adrenoceptor beta-2 (ADRB2) is a novel checkpoint receptor that inhibits T cell-mediated anti-tumor responses. To inhibit ADRB2-mediated inhibitory signaling, we downregulated ADRB2 in CAR-T (shβ-CAR-T) cells via RNA interference, assessed different parameters, and compared them with conventional second-generation CAR-T cells.
View Article and Find Full Text PDFCbl-b inhibition promotes less differentiated phenotypes of T cells with enhanced cytokine production.
Cell Immunol
September 2024
Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China; Chongqing Key Laboratory of Tumor Immune Regulation and Immune Intervention, Chongqing 400010, China. Electronic address:
For adoptive therapy with T cell receptor engineered T (TCR-T) cells, the quantity and quality of the final cell product directly affect their anti-tumor efficacy. The post-transfer efficacy window of TCR-T cells is keen to optimizing attempts during the manufacturing process. Cbl-b is a E3 ubiquitin ligase previously shown with critical negative impact in T cell functions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!