Objective: To examine the biocompatibility of polylactic/glycolic acid (PLGA) and Schwann cells.
Method: Schwann cells were harvested from rat brachial and sciatic nerves. Schwann cells were cultured with PLGA, observed by phase-contrast microscopy and electron microscopy.
Result: Schwann cells could attach and proliferate on the surface of the PLGA.
Conclusion: The PLGA has good cellular biocompatibility. It can be used as biomaterial for tissue engineering.
Download full-text PDF |
Source |
---|
Alzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: Neuroimaging-based evidence suggests that changes in cerebral tissue determinants, including axonal density and myelin content, are associated with aging and neurodegenerative diseases. While neuroimaging markers show strong association with physiological changes, direct validation of their specificity remains challenging. Histology provides useful information for validation, however, faces limitations including denaturation of the sample during preparation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: In 2016, we introduced the Bayesian Monte Carlo analysis of multicomponent-driven equilibrium observation of T and T (BMC-mcDESPOT) MRI method for myelin water fraction (MWF) mapping, a surrogate of myelin content. While BMC-mcDESPOT has been extensively applied to study brain aging, dementias, and risk factors influencing myelination, it still requires a lengthy acquisition time (∼17 min) which hampers its integration in clinical studies and trials. In this study, we aim to accelerate the BMC-mcDESPOT method for whole brain, high-resolution, MWF mapping within clinically feasible scan time of ∼6 min.
View Article and Find Full Text PDFBackground: Myelin integrity is central to healthy brains and is increasingly shown to be compromised in neurodegenerative diseases. Diffusion- and susceptibility-based MRI metrics can detect myelin changes. We show advanced diffusion and susceptibility metrics can detect degenerative myelin changes in ex vivo AD and HD mouse models.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: Cognitive decline during normative aging significantly impacts the quality of life, while the rate varies among individuals. MRI studies have highlighted the correlation between cognitive functions and brain macrostructure. However, cerebral microstructural alterations, especially in white matter, may precede macrostructural changes, driving early cognitive decline.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: Age-related white matter (WM) deterioration has been associated with several neurodegenerative diseases, including Alzheimer's disease. Studies suggest that cardiorespiratory fitness (CRF) is important in preserving WM structure and function. However, clinical investigations of the relationship between myelin integrity and CRF are lacking.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!