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| http://dx.doi.org/10.1073/pnas.0803068105 | DOI Listing |
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High Overexpression of Leads to Growth Inhibition and Protein Ectopic Localization in Transgenic .
Int J Mol Sci
May 2024
College of Agriculture, Shanxi Agricultural University, Jinzhong 030801, China.
Article Synopsis
- Amino acid permeases (AAPs) are vital for transporting amino acids in plants, but studies on foxtail millet are less advanced compared to crops like rice.
- This research identified two AAP transcripts that are induced by nitric oxide, with one (SiAAP9) transporting more amino acids and having a significant impact on seed growth.
- SiAAP9 also showed increased tolerance to glutamate and histidine, and its enhanced amino acid transport capabilities suggest it could improve the nutritional quality of foxtail millet through selective breeding.
Circular RNA Gtdc1 Protects Against Offspring Osteoarthritis Induced by Prenatal Prednisone Exposure by Regulating SRSF1-Fn1 Signaling.
Adv Sci (Weinh)
May 2024
Department of Orthopedic Surgery, Joint Disease Research Center of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Chondrodysplasia is closely associated with low birth weight and increased susceptibility to osteoarthritis in adulthood. Prenatal prednisone exposure (PPE) can cause low birth weight; however, its effect on offspring cartilage development remains unexplored. Herein, rats are administered clinical doses of prednisone intragastrically on gestational days (GDs) 0-20 and underwent long-distance running during postnatal weeks (PWs) 24-28.
View Article and Find Full Text PDFDynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis.
bioRxiv
September 2023
Cell Signalling Unit, Children's Medical Research Institute, The University of Sydney, Locked Bag 23, Wentworthville 2145, NSW, Australia.
Dynamin 1 (Dyn1) has two major splice variants, xA and xB, with unique C-terminal extensions of 20 and 7 amino acids, respectively. Of these, only Dyn1xA is enriched at endocytic zones and accelerates vesicle fission during ultrafast endocytosis. Here, we report that the long tail variant, Dyn1xA, achieves this localization by preferentially binding to Endophilin A through a newly defined Class II binding site overlapping with its extension, at a site spanning the splice boundary.
View Article and Find Full Text PDFSplicing Measurement and Compensation of Straightness Errors for Ultra-Precision Guideways.
Micromachines (Basel)
August 2023
Research Center of Laser Fusion, China Academy of Engineering Physics, Chengdu 610093, China.
The straightness error of guideways is one of the key indicators of an ultra-precision machine, which plays an important role in the machining accuracy of a workpiece. In order to measure the straightness error of a long-distance ultra-precision guideway accurately, a splicing measurement for the straightness error of a guideway using a high-precision flat mirror and displacement sensor was proposed in this paper, and the data splicing processing algorithm based on coordinate transformation was studied. Then, comparative experiments on a splicing measurement and direct measurement of the straightness error were carried out on a hydrostatic guideway grinder.
View Article and Find Full Text PDFPredicting Plant miRNA-lncRNA Interactions via a Deep Learning Method.
IEEE Trans Nanobioscience
October 2023
In recent years, due to the contribution to elucidating the functional mechanisms of miRNAs and lncRNAs, the research on miRNA-lncRNA interaction prediction has increased exponentially. However, the prediction research is challenging in bioinformatics domain. It is expensive and time-consuming to verify the interactions by biological experiments.
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