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Vitiligo-Like Depigmentation following Treatment with Imiquimod 5% Cream for Condylomata Acuminata.
Case Rep Dermatol
January 2021
Department of Dermatology, Derma Clinics, Riyadh, Saudi Arabia.
Imiquimod cream is an immunomodulatory agent that has been approved by the US Food and Drug Administration for use in the treatment of anogenital warts (condylomata acuminata) due to its local immune effects in activating Toll-like receptors 7 and 8 on antigen-presenting cells, resulting in reduction of the viral load of human papillomavirus with subsequent wart regression. After its application, some side effects are commonly reported, including erythema, edema, scaling, erosion, and ulceration. While pigmentary changes, including vitiligo-like depigmentation, have been mentioned as a possible side effect, they have rarely been reported in the literature.
View Article and Find Full Text PDFGenital Vitiligo-like Hypopigmentation After Treatment With 5% Imiquimod.
Actas Dermosifiliogr
May 2017
Departamento de Dermatología, Hospital Costa del Sol, Marbella, Málaga, España.
Vitiligo-like lesions following imiquimod 5% application for condyloma acuminata: An additional case.
Indian J Dermatol Venereol Leprol
April 2017
Department of Dermatology, Dermatologist - Venereologist, Hammoud Hospital University Medical Center, Beirut, Lebanon.
Association of vitiligo and response in patients with metastatic malignant melanoma on temozolomide.
Tumori
July 2015
Department of Medical Oncology, Van Training and Research Hospital, Van - Turkey.
Vitiligo-like lesions, although rare, are believed to be a prognostic factor in malignant melanoma. While a predictive role for such lesions was shown with immunomodulatory therapies, this relation was not demonstrated with temozolomide. We present 3 patients with metastatic malignant melanoma who developed vitiligo-like skin lesions accompanying good response to treatment and prolonged survival.
View Article and Find Full Text PDFVulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events?
An Bras Dermatol
April 2015
Divisione Melanoma, Istituto Europeo di Oncologia, Milano, Italia.
A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months follow-up genital depigmentation persisted and halo nevi of the trunk were still present.
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