AI Article Synopsis
- * Angiogenesis is crucial for the growth and spread of NSCLC tumors, making the vascular endothelial growth factor (VEGF) pathway a key therapeutic target that has been validated through various early clinical trials.
- * Early trial data indicates that using angiogenesis inhibitors alongside standard chemotherapy may enhance their effectiveness, but the best combination with minimal side effects is still to be discovered.
Article Abstract
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality in the United States. Therapeutic agents that target the underlying biology of this disease are necessary to improve outcomes. Angiogenesis plays a central role in NSCLC tumor growth and metastases. The vascular endothelial growth factor pathway (VEGF) as a therapeutic target was recently validated in NSCLC. Since then, a multitude of early phase clinical trials that incorporate the use of angiogenesis inhibitors, either as single agents or in combination with cytotoxic chemotherapy, have been conducted in advanced, refractory NSCLC. This article reviews these clinical trials with attention to toxicity, efficacy, and direction of further study. The data from these trials suggest that optimal use of anti-angiogenic agents in NSCLC is more likely in combination with standard cytotoxic agents, however the most effective combination with the least toxicity is yet to be determined.
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| http://dx.doi.org/10.2174/157488707780599401 | DOI Listing |
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