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Artemisinin-Quinidine Combination for Suppressing Ventricular Tachyarrhythmia in an Ex Vivo Model of Brugada Syndrome.
J Korean Med Sci
January 2025
Division of Cardiology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Background: The ionic mechanism underlying Brugada syndrome (BrS) arises from an imbalance in transient outward current flow between the epicardium and endocardium. Previous studies report that artemisinin, originally derived from a Chinese herb for antimalarial use, inhibits the Ito current in canines. In a prior study, we showed the antiarrhythmic effects of artemisinin in BrS wedge preparation models.
View Article and Find Full Text PDFSynthesized V7 QRS Amplitude and Oversensing Episodes in Patients With Subcutaneous Implantable Cardioverter-Defibrillators.
Pacing Clin Electrophysiol
December 2024
Department of Cardiology, Anjo Kosei Hospital, Anjo, Japan.
Article Synopsis
- Patients with subcutaneous implantable cardioverter-defibrillators (S-ICDs) experience oversensing episodes (OS) more frequently than those with traditional transvenous ICDs, indicating a need for better detection methods.
- A study of 21 patients found that 28.6% experienced OS, particularly among those with Brugada/J wave syndrome, and determined that a significantly lower QRS amplitude in the synthesized V7 lead (synV7) was linked to OS incidence.
- The study suggests that a synV7 QRS amplitude of less than 0.61 mV can effectively predict the occurrence of OS, highlighting the need for monitoring this parameter in patients with S-ICDs.
Late gadolinium enhancement in early repolarization syndrome.
Heart Rhythm
July 2024
Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
Background: In patients with Brugada syndrome, myocardial fibrosis can be identified through epicardial biopsy or cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE). However, the myocardial alterations in patients with early repolarization syndrome (ERS) remain poorly elucidated.
Objective: The objective of this study was to investigate the presence of myocardial fibrosis in patients with ERS by LGE in CMR.
Skin sympathetic nerve activity and ST-segment depression in women.
Heart Rhythm O2
June 2024
Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Background: ST-segment depression (ST depression) on exercise electrocardiogram (ECG) and ambulatory ECG monitoring may occur without myocardial ischemia. The mechanisms of nonischemic ST depression remain poorly understood.
Objective: The study sought to test the hypothesis that the magnitudes of skin sympathetic nerve activity (SKNA) correlate negatively with the ST-segment height (ST height) in ambulatory participants.
Demonstration of Arrhythmia Substrate-Associated Dispersion of Repolarization by Epicardial Unipolar Mapping in Brugada Syndrome.
JACC Clin Electrophysiol
July 2024
Division of Arrhythmia, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Article Synopsis
- The study investigates epicardial unipolar mapping in patients with Brugada syndrome (BrS) and compares it to patients with cardiomyopathy to identify unique characteristics.
- Findings reveal that patients with BrS have significantly higher J-wave amplitudes and a greater repolarization time dispersion index, which can be indicative of the syndrome with high sensitivity and specificity.
- The research highlights that the steep repolarization gradients observed in BrS patients may contribute to arrhythmias, suggesting a unique electrical profile that differentiates it from cardiomyopathy.
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