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| http://dx.doi.org/10.1289/ehp.11096 | DOI Listing |
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Prune belly syndrome (PBS), or Eagle-Barrett syndrome, is a rare congenital disorder marked by abdominal wall muscle deficiency, urinary tract anomalies, and cryptorchidism, causing significant abdominal wall laxity and functional impairment. This case report discusses an innovative approach to abdominal wall reconstruction in a 19-year-old male patient with PBS and associated conditions, including chronic renal failure and spina bifida. Previously, he underwent distal ureterectomy and vesicoureteral reimplantation at the age of two years to correct urinary tract dilation and bilateral orchiopexy.
View Article and Find Full Text PDFIn vitro effect of hCG on cryptorchid patients' gubernacular cells: a predictive model for adjuvant personalized therapy.
Cell Commun Signal
January 2025
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Background: Cryptorchidism is the absence of one or both testicles in the scrotum at birth, being a risk factor for testis cancer and infertility. The most effective method to treat cryptorchidism is orchiopexy, followed by human chorionic gonadotropin (hCG) therapy; however, a portion of treated patients do not show a significant improvement in testis volume and vascularization after adjuvant therapy.
Methods: In this study, we generated an in vitro model to predict the patient response to hCG by cultivating and treating primary cells derived from five cryptorchid patients' biopsies of gubernaculum testis, the ligament that connects the testicle to the scrotum.
The Role of Laparoscopy in Managing Impalpable Undescended Testes in a Tertiary Hospital.
Mymensingh Med J
January 2025
Dr Mohammad Showkot Ali, Assistant Professor, Department of Pediatric Surgery, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:
One of the most prevalent congenital defects in boys is undescended testes. Ultrasound is commonly employed to locate the testis in cases of impalpable testes, which frequently yields false-negative results. Laparoscopy has gained widespread acceptance recently for managing impalpable testes.
View Article and Find Full Text PDFPlatelet-rich plasma effects on in vitro cells derived from pediatric patients with andrological diseases.
Sci Rep
December 2024
Department of Neurosciences, Biomedicine and Movement Sciences, Biochemistry Section, University of Verona, Verona, Italy.
Undescended testis and testicular torsion represent two frequent andrological diseases that affect the pediatric age. Despite these testicular disorders having different causes, they both negatively influence fertility in adulthood mainly due to the accumulation of reactive oxygen species (ROS), which represents the primary molecular damage underlying their long-term effects. The gold standard of treatment for both pathologies is surgery; however, it cannot guarantee an optimal fertility outcome in all clinical cases, underscoring the need to identify effective adjuvant therapies that may target the augmented ROS levels.
View Article and Find Full Text PDFIs anti-müllerian hormone useful for monorchidism diagnosis in the tomcat?
Top Companion Anim Med
January 2025
Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Monorchidism is an uncommon condition in tomcats, defined by the congenital absence of one of the testicles. Due to the lack of information regarding possible biomarkers, most monorchidism cases require laparotomy in order to differentiate it from cryptorchidism. Human data suggest that monorchid patients have lower serum anti-Müllerian hormone (AMH) levels when compared to cryptorchids, premises that has been also scrutinized in veterinary medicine.
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