Interstitial pneumonia can be controlled by the combined use of a prophylactic antibiotic system and the drip infusion system including megadose vitamin C, dehydroepiandrosterone (D) and cortisol (F), a fortified substitute of 3 adrenocortical elements. The response of patients was satisfying with few side-effects of F. It was shown that an excess of vitamin C improved the therapeutic efficacy of D-F complex, and that D and F improved the immunodeficient state of the host. The benefit of D as an adrenal androgen in immunology found another example in the combined use of cyclosporine A (CS) and glucocorticoid (G) in the kidney transplantation clinic: CS and G helps improve graft take by creating a state of androgen excess, as testified in both humans and mice--an alleviation of immune conflict.

Download full-text PDF

Source

Publication Analysis

Top Keywords

interstitial pneumonia
8
drip infusion
8
megadose vitamin
8
vitamin dehydroepiandrosterone
8
dehydroepiandrosterone cortisol
8
control interstitial
4
pneumonia drip
4
infusion megadose
4
cortisol short
4
short review
4

Similar Publications

Dendriform pulmonary ossification in military combat veterans: A case series.

Respir Med Case Rep

December 2024

Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA.

Dendriform pulmonary ossification (DPO) is a rare condition characterized by mature bone formation in the lung. DPO has been linked to various conditions, but little is known about the link between DPO and hazardous airborne exposures. We queried research databases of military personnel evaluated for deployment-related respiratory diseases at two occupational pulmonary medicine clinics (Colorado, USA) for diagnoses of DPO, and summarized demographics, Gulf War military deployment history, medical history, and pulmonary function testing.

View Article and Find Full Text PDF

Fibrosis in PCLS: comparing TGF-β and fibrotic cocktail.

Respir Res

January 2025

Department for Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Introduction: Fibrotic cocktail (FC) is a combination of pro-fibrotic and pro-inflammatory mediators that induces early fibrotic changes in organotypic lung models. We hypothesised that transforming growth factor beta 1 (TGF-β1) alone induces a pro-fibrotic effect similar to FC. Our aim was to compare the pro-fibrotic effects of TGF-β1 with FC in human precision-cut lung slices (PCLS).

View Article and Find Full Text PDF

The degree of cross-linking of polyacrylic acid affects the fibrogenicity in rat lungs.

Sci Rep

January 2025

Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.

Polyacrylic acid (PAA) with different concentrations of cross-linker was instilled into the trachea of rats to examine the effect of PAA crosslink density on lung disorders. Methods: F344 rats were intratracheally exposed to low and high doses of PAA with cross-linker concentrations of 0.1, 1.

View Article and Find Full Text PDF

Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulence.

Nat Commun

January 2025

Functional Genomics & Bioinformatics Laboratory, Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses in the global swine industry due to its high genetic diversity and different virulence levels, which complicate disease management and vaccine development. This study evaluated longitudinal changes in the immune cell composition of bronchoalveolar lavage fluid and the clinical outcomes across PRRSV strains with varying virulence, using techniques including single-cell transcriptomics. In highly virulent infection, faster viral replication results in an earlier peak lung-damage time point, marked by significant interstitial pneumonia, a significant decrease in macrophages, and an influx of lymphocytes.

View Article and Find Full Text PDF

Epidemiologic survey for work-related idiopathic interstitial pneumonias focusing on idiopathic pulmonary fibrosis in Korea, 2010-2022.

J Occup Environ Med

January 2025

Department of Research for Occupational Health, Institute of Occupation and Environment, Korea Workers' compensation & Welfare Service, Incheon, Republic of Korea.

Objective: This study aimed to share the process of epidemiologic survey and demonstrate the decisive factors for evaluating work-related Idiopathic interstitial pneumonias (IIPs) in Korea.

Methods: Data and reports of epidemiologic surveys were investigated and completed during 2010-2022.

Results: A total of 228 idiopathic pulmonary fibrosis (IPF) cases requested for an epidemiologic survey, of which 153 (67.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!