AI Article Synopsis
- Mammary gland adenomyoepitheliomas are generally benign tumors made up of neoplastic cells from both epithelial and myoepithelial origins, found in various species including humans and dogs, but are rarely reported in mice.
- The study details a case of such a tumor in a C57BL/6 female mouse, characterized by neoplastic epithelial cells forming tubes and cords, surrounded by myoepithelial cell bundles in a clear, partially mucinous matrix.
- Immunohistochemical analysis revealed that the epithelial cells were strongly positive for cytokeratin, while myoepithelial cells showed weak cytokeratin positivity and strong positivity for smooth muscle actin, marking this as the first documented case of
Article Abstract
Mammary gland adenomyoepitheliomas are benign complex mammary gland tumors composed of neoplastic cells of epithelial and myoepithelial origins, described in many species (humans, dogs, cats, rats) and rarely in mice. We report here an adenomyoepithelioma in a C57BL/6 female mouse. Histologically, tubes and cords formed by neoplastic epithelial cells were separated by bundles of neoplastic myoepithelial cells in a clear and partially mucinous matrix. The tumor displayed characteristics of a benign neoplastic proliferation with a compressive growth pattern, and moderate cellular pleomorphism and mitotic index. At immunohistochemistry, the epithelial cells were strongly cytokeratin positive; the myoepithelial cells were weakly cytokeratin positive and strongly smooth muscle actin positive. This is to our knowledge, the first report of a mammary gland adenomyoepithelioma in a C57BL/6 mouse.
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| http://dx.doi.org/10.1016/j.etp.2008.02.008 | DOI Listing |
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