The filarial parasite Loa loa is transmitted by Chrysops fly bites. Loiasis is endemic in rainforest areas of West and Central Africa, and sporadic cases have also been diagnosed in travellers and migrants. Whilst many infected persons are asymptomatic, microfilariae may be detected in the blood or adult worms may be seen under the skin or the sclera of the eye. Mass treatment programmes for onchocerciasis have raised concern about the risk of severe adverse effects when ivermectin is distributed in areas co-endemic for onchocerciasis and loiasis.
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http://dx.doi.org/10.1016/j.trstmh.2008.03.022 | DOI Listing |
IDCases
October 2024
Sheikh Khalifa Medical City, Al Tibbiya, Abu Dhabi, United Arab Emirates.
The 'African eye worm', also known as Loa loa, is filarial nematode that is commonly, transmitted by deer flies. A history of recent travel to endemic countries near western, Africa is common in patients with Loiasis. While a majority of patients infected with Loa, loa are asymptomatic, common presentations of Loiasis include localized areas of, edema, Calbar swellings, and ocular symptoms secondary to the migration of worms, through the spaces within the eye.
View Article and Find Full Text PDFPLoS Negl Trop Dis
May 2024
Center for Tropical Medicine, Bernhard-Nocht Institute for Tropical Medicine and I. Department of Medicine University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Background: More than 20 million people are infected with L. loa, and around 40 million live in high or intermediate-risk areas in West- and Central Africa. Although loiasis is associated with significant morbidity and excess mortality, little is known about the perception of loiasis by affected communities.
View Article and Find Full Text PDFParasit Vectors
October 2023
UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (WHO/TDR), World Health Organization, Geneva, Switzerland.
Lancet Infect Dis
March 2024
Department of Clinical Research, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Division of Tropical Medicine, I Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Centre de Recherche Médicale de Lambaréné, Lambaréné, Gabon.
Loa loa, the African eye worm, is a filarial pathogen transmitted by blood-sucking flies of the genus Chrysops. Loiasis primarily affects rural populations residing in the forest and adjacent savannah regions of central and west Africa, where more than 20 million patients are chronically infected in medium and high transmission regions. For a long time, loiasis has been regarded as a relatively benign condition.
View Article and Find Full Text PDFPLoS Negl Trop Dis
August 2023
Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Background: There is a lack of systematic evidence for strategies to control loiasis transmission in highly endemic regions. Here we assessed albendazole and ivermectin based treatment regimens to reduce Loa loa microfilaraemia in Gabon.
Methods: Eligible adult patients with L.
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