The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. The oxidative coupling takes place in the presence of 5-10 mol % of Pd(OAc)2, 10-20 mol % of DMSO, and 4-11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2489205 | PMC |
| http://dx.doi.org/10.1021/ol800619c | DOI Listing |
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