Ceramide 1-phosphate (C1P) possesses emerging and diversified roles in the regulation of various physiological and pathological processes, including cell proliferation, apoptosis and inflammation. Data have established a proinflammatory role for C1P and have also produced information on the structure, function, substrate specificity and regulatory mechanisms of its synthesizing enzyme, ceramide kinase (CERK). This review focuses on the rationale for designing specific inhibitors of CERK and provides evidence for the potential of CERK inhibition as a promising anti-inflammatory therapy.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
ceramide kinase
8
kinase potential
4
potential anti-inflammatory
4
anti-inflammatory target?
4
target? ceramide
4
ceramide 1-phosphate
4
1-phosphate c1p
4
c1p possesses
4
possesses emerging
4
emerging diversified
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!