Atrazine exposure decreases cell proliferation in Chinese Hamster Ovary (CHO-K1) cell line.

Bull Environ Contam Toxicol

Faculty of Food Technology and Biotechnology, University of Zagreb, Pierotti St 6, 10000, Zagreb, Croatia.

Published: August 2008

The aim of this study was to determine the toxic effect of atrazine at the ovarian cellular level. Chinese Hamster Ovary (CHO-K1) cell line was used to evaluate the degree of in vitro atrazine cytotoxicity and the morphological changes were followed during the cell death. Application of four bioassays confirmed that atrazine decreases ovarian cell proliferation and IC(50) were determined with each assay after 72 h of exposure. The level of apoptosis in atrazine treated cells was low.

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http://dx.doi.org/10.1007/s00128-008-9425-6DOI Listing

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