There are the methods made various regenerative tissue from embryonic stem cell and tissue stem cell for regenerative medicine. We have performed the basic studies to product the regenerative bone and cartilage with mesenchymal stem cell included in bone marrow. Based on the results, we have cultured patient's bone marrow in cell processing center after approval of our ethic committee and placed the regenerative bone and cartilage on scaffolds and total prostheses. These materials were replaced on lesions of bone and joint diseases by cartilaginous damage, osteoarthritis, bone tumor and congenital anomaly. The follow-up periods are not so long, because they were started from 2001. The good results of them without rejection and infection have been obtained for the present.
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Sci Rep
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