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The trustworthiness of registered randomised control trials on hysteroscopy.
Eur J Obstet Gynecol Reprod Biol
February 2025
Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia; Monash Women's, Monash Health, Clayton, Victoria, Australia; Aberdeen Centre for Women's Health Research, University of Aberdeen, Aberdeen, UK. Electronic address:
Introduction: The objective of this study was to assess the publication status of RCTs studying hysteroscopy registered on clinical trial registries, and the trustworthiness of these studies.
Material And Methods: We systematically searched 23 clinical trial registries and MEDLine for studies on hysteroscopy registered between March 2012 and 25 March 2022. Published RCTs were assessed for trustworthiness using the Trustworthiness in RAndomised Controlled Trials (TRACT) checklist.
Janus LAAM-loaded electrospun fibrous buccal films for treating opioid use disorder.
Biomaterials
December 2024
Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, 23298, USA; Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA, 23298, USA; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, 23298, USA; Center for Pharmaceutical Engineering, Center for Drug Discovery, Department of Pediatrics, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address:
The opioid crisis has claimed approximately one million lives in the United States since 1999, underscoring a significant public health concern. This surge in opioid use disorder (OUD) fatalities necessitates improved therapeutic options. Current OUD therapies often require daily clinical visits, leading to poor patient compliance and high costs to the health systems.
View Article and Find Full Text PDFTotal arsenic and inorganic arsenic in Myanmar rice.
Heliyon
December 2024
Department of Earth and Environmental Sciences and Williamson Research Centre for Molecular Environmental Sciences, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, M13 9PL, United Kingdom.
Myanmar is a major rice exporter. Rice is an important source of nourishment for its population. However, rice can be contaminated with toxic elements, including arsenic, long-term exposure to which has been linked to several illnesses, including cancer.
View Article and Find Full Text PDFBackground: Cluster-randomized controlled trials (cluster-RCTs) have demonstrated variation in the epidemiological efficacy of different next-generation insecticide-treated net (ITN) types, with some providing shorter-lived impact than others. Further studies are needed to assess changes in the insecticidal durability of these ITNs over time to complement cluster-RCT results.
Methods: A series of experimental hut trials were performed to evaluate the bioefficacy of new and field-aged next-generation ITNs (PermaNet 3.
Overt and hidden polymorphism in the binary system involving the Z- and E- isomers of broparestrol.
Int J Pharm
January 2025
Laboratoire SMS, UR 3233, Université de Rouen Normandie, Normandie Université, F76000, Rouen, France. Electronic address:
Broparestrol has been used as a drug to treat acne in the form of a mixture of its two stereoisomers. Although it has been withdrawn from the market, the binary system is rich in polymorphism and understanding the phase behaviour of the binary system involving the E- and Z-isomers is challenging. Physical mixtures do not immediately give rise to equilibrium phase behaviour, whereas recrystallization often leads to metastable phases and the appearance of stable phases can take years.
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