AI Article Synopsis
- Perioral dermatitis (POD) is common but lacks standard treatment, prompting a study on the effectiveness of pimecrolimus cream 1%.
- A multicenter, randomized study showed that patients using pimecrolimus had significantly lower POD Severity Index scores compared to those using a vehicle cream, particularly benefiting those with a history of corticosteroid use.
- Pimecrolimus led to faster clinical improvements and better quality of life for patients, though the study acknowledges that the vehicle used isn't a true placebo.
Article Abstract
Background: Perioral dermatitis (POD) is a common dermatosis without standard therapy.
Objective: We sought to evaluate pimecrolimus cream 1% in POD.
Methods: We conducted a multicenter, randomized, double-blind, parallel-group study in adult patients with POD treated twice daily with pimecrolimus cream 1% or vehicle until clearance for up to 4 weeks. Follow-up took place 4 and 8 weeks after treatment.
Results: Patients treated with pimecrolimus had an average POD Severity Index score of 2.6 compared with 3.5 for patients treated with vehicle. Both groups had baseline scores of 5.2. The between-group difference was 0.9 (95% confidence level 0.4, 1.4, P = .0011). Patients with history of topical corticosteroids benefited most. Pimecrolimus-treated patients reported greater improvement in quality of life. There were no group differences regarding safety.
Limitations: Pimecrolimus vehicle is not a true placebo.
Conclusions: Pimecrolimus rapidly improves clinical symptoms and quality of life of patients with POD, being most effective in corticosteroid-induced POD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaad.2008.03.043 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lichen Planus Treated with Individualized Homeopathic Medicine, A Case Report.
Altern Ther Health Med
April 2024
Context: Lichen planus (LP) is a chronic lichenoid inflammatory disease of the skin, mucosa and appendages. The classic LP symptom is a dense infiltration of inflammatory T cells moving in the upper dermis and arranged in a band-like pattern. Lichen planus has an undetermined aetiology; however, it is known to have immune-mediated pathogenesis.
View Article and Find Full Text PDFPimecrolimus 1% cream for mild-to-moderate atopic dermatitis: a systematic review and meta-analysis with a focus on children and sensitive skin areas.
Eur J Dermatol
October 2023
Department of Dermatology and Venereology National Clinical Research Center for Skin and Immune Diseases, Peking University First Hospital, Beijing, China.
This systematic literature review (SLR) and meta-analysis assessed the efficacy and safety of pimecrolimus vs other topical treatments in patients with mild-to-moderate atopic dermatitis (AD), focusing on children and sensitive skin areas. An SLR was conducted in MEDLINE, Embase and Cochrane Library databases on January 15th, 2020, to identify randomized controlled trials (RCTs) with pimecrolimus as a study arm. Another SLR performed on October 5th, 2020 identified RCTs with a crisaborole study arm.
View Article and Find Full Text PDFMorphea Involving the Lips and Gingiva: A Rare Case Report.
Cureus
December 2023
College of Dentistry, King Saud University, Riyadh, SAU.
Morphea is a subtype of scleroderma that does not involve Raynaud's phenomenon or internal organ involvement. It is a connective tissue disease that features the excessive deposition of collagen in the dermis and subcutaneous tissue, leading to a thickening of the dermis and subcutaneous tissue, eventually forming a scar-like lesion. We represent a 19-year-old male Saudi patient displaying a white patch on the marginal gingiva of tooth #21 and multiple yellowish papules on the outer surface of the lip.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!