Neurotoxicity of chemotherapeutic and biologic agents in children with cancer.

Curr Neurol Neurosci Rep

Division of Neurology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA.

Published: March 2008

The sequelae of treatment modalities used to treat childhood cancer are of increasing clinical importance. In children with pediatric malignancies, the full impact of such sequelae may not be apparent until years after treatment. The earlier recognition of these neurotoxicities could possibly alter the course of a treatment or facilitate interventions to improve quality of life.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11910-008-0019-9DOI Listing

Publication Analysis

Top Keywords

neurotoxicity chemotherapeutic
4
chemotherapeutic biologic
4
biologic agents
4
agents children
4
children cancer
4
cancer sequelae
4
sequelae treatment
4
treatment modalities
4
modalities treat
4
treat childhood
4

Similar Publications

5-Fluorouracil (5-Fu) is the third-most often used chemotherapeutic medication and has been scientifically demonstrated to be effective in treating solid tumors, including colorectal, stomach, cutaneous, and breast cancers. When used in excess, it accumulates toxic metabolites, which can have deadly and very harmful effects on people, including neurotoxicity and the induction of morbidity. Therefore, sensitive and rapid analytical techniques for detecting 5-Fu in human blood serum are needed to enhance chemotherapy and forecast the possible adverse effects of 5-Fu residues in the human body.

View Article and Find Full Text PDF

Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced neurotoxicity in male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts and treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) and DEN-only (200 mg/kg; single dose i.

View Article and Find Full Text PDF

Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g.

View Article and Find Full Text PDF

Chemotherapy-Induced Neuropathy Affecting the Gastrointestinal Tract.

Neurogastroenterol Motil

December 2024

Department of Basic Health Sciences, University Rey Juan Carlos (URJC), Alcorcón, Spain.

Article Synopsis
  • Cancer treatments can lead to severe gastrointestinal side effects, both acute (short-term) and chronic (long-term), impacting patients' overall health.
  • This article reviews chemotherapy's neurotoxic effects on the enteric nervous system (ENS) and how chemotherapy-induced enteric neuropathy (CIEN) may cause persistent gastrointestinal dysfunctions.
  • Research indicates that CIEN results in reduced nerve cell density and altered neuronal activity in the ENS, affecting gut functions and potentially leading to brain-gut axis disorders, highlighting the need for more research in this overlooked area.
View Article and Find Full Text PDF

Background: Platina and taxanes are frequently used chemotherapeutic agents to treat cancer, also when diagnosed during pregnancy. This report presents an interim analysis of the largest series of children prenatally exposed to platinum and/or taxane agents and aims to determine their physical health and neurocognitive outcomes.

Methods: As part of a multicentre, prospective cohort study (ClinicalTrials.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!