AI Article Synopsis
- The study aimed to investigate a possible link between blood group B and congenital cardiac defects in a larger group of patients, following earlier observations in a small sample of African-American children.
- Researchers analyzed data from 1,985 patients undergoing cardiac surgery, categorizing them into six diagnostic subgroups, and compared their ABO blood group distributions to those found in the general U.S. population.
- The findings revealed no significant relationship between ABO blood phenotypes and congenital cardiac defects, suggesting that the earlier reported association may not hold true in a larger, more diverse population.
Article Abstract
Background: Cardiac anomalies are among the most frequent congenital malformations, but the basic underlying causes for most cardiac defects remains undetermined. Some 40 years ago, a higher incidence of blood group B was reported in a small number of African-American children with congenital cardiac defects. In this study, we sought to re-evaluate this association using a larger population.
Methods And Results: We collected data from 1985 patients undergoing cardiac surgery from July, 2000, through December, 2004. We divided the patients into 6 subgroups according to their diagnosis. We then compared the prevalence of ABO phenotypes between the patients and the general population of the United States of America by chi-square analysis. There were no significant differences in the distribution of the ABO phenotypes amongst the subgroups of those with congenital cardiac disease, or any for subgroup compared to the general population.
Conclusion: While statistical significance is influenced by the size of the population within the United States of America and the small numbers within each of our subgroups of patients with congenital cardiac disease, we have been unable to show any relationship between the distribution of ABO phenotypes and the existence of congenital cardiac disease.
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| http://dx.doi.org/10.1017/S104795110800231X | DOI Listing |
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