Synthesis of a new intermediate for bioactive Lamellarins.

This paper reports two methods of synthesis for 1,2,4-trimethoxy-5-(1-methyl-2-phenyl-vinyl)-benzene, which was a key intermediate to synthesize the various Lamellarins. One method is by using the Wittig-Horner reaction and another is by the Grignard reaction. By conducting contrast experiments, we got the optimal reaction parameters for high yields. The newly formed intermediate was identified by means of IR spectrum, (1)H-NMR, (13)C-NMR and melting point measurements.