AI Article Synopsis
- The study tested doxycycline hyclate in rodent bait at 250 and 500 mg/Kg for preventing and treating Lyme borreliosis in mice.
- Both bait formulations completely prevented infections in 100% of mice and also cured acute infections in a significant number of treated mice.
- The results showed that the antibiotic effectively cleared Borrelia burgdorferi from infected ticks, suggesting a new approach to prevent Lyme disease transmission.
Article Abstract
The prophylactic and curative potential of doxycycline hyclate formulated in a rodent bait at concentrations of 250 and 500 mg/Kg was evaluated in a murine model of Lyme borreliosis. Both bait formulations prevented tick-transmitted Borrelia burgdorferi infection in 100% of C3H/HeJ mice (N = 16), as well as cured acute, established infection in mice (N = 8) exposed to bait for 14 days. Spirochete infection was cleared in 88.9% to 100% of infected nymphs feeding on mice fed 250 and 500 mg/Kg antibiotic bait formulations, respectively. These data provide evidence for exploring alternative techniques to prevent transmission of Lyme disease spirochetes.
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