This work presents an innovative nanorobot architecture based on nanobioelectronics for diabetes. The progressive development toward the therapeutic use of nanorobots should be observed as the natural result from some ongoing and future achievements in biomedical instrumentation, wireless communication, remote power transmission, nanoelectronics, new materials engineering, chemistry, proteomics, and photonics. To illustrate the nanorobot integrated circuit architecture and layout described here, a computational approach with the application of medical nanorobotics for diabetes is simulated using clinical data. Integrated simulation can provide interactive tools for addressing nanorobot choices on sensing, hardware design specification, manufacturing analysis, and methodology for control investigation. In the proposed 3D prototyping, a physician can help the patient to avoid hyperglycemia by means of a handheld device, like a cell phone enclosed with cloth, that is used as a smart portable device to communicate with nanorobots. Therefore, this architecture provides a suitable choice to establish a practical medical nanorobotics platform for in vivo health monitoring.
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http://dx.doi.org/10.1016/j.nano.2008.03.001 | DOI Listing |
Curr Drug Deliv
January 2025
Laboratory of Molecular Medicine, Birla Institute of Technology and Sciences Pilani Hyderabad Campus, 500071, India.
Recent advancements in nanotherapeutics have revolutionized cancer treatment through the integration of diagnostic and therapeutic modalities, known as theranostics. This critical review examines the current landscape of nanotherapeutics for various cancers, such as bladder and head and neck squamous cell carcinoma, highlighting current advancements in nanotherapeutics and challenges. Key approaches discussed include biomimetic smart nanocarriers, polymeric smart nanocarriers, inorganic-based smart nanocarriers, and nanorobots.
View Article and Find Full Text PDFPurpose: UGN-101, a reverse thermal mitomycin gel for upper tract instillation, recently became the first FDA approved treatment for upper tract urothelial carcinoma (UTUC). However, the durability of UGN-101 treatment has not been well described. Here we present long term outcomes from our multi-institutional cohort for patients who initially responded to treatment.
View Article and Find Full Text PDFChem Soc Rev
January 2025
Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00, Brno, Czech Republic.
In the dynamic realm of translational nanorobotics, the endeavor to develop nanorobots carrying therapeutics in rational applications necessitates a profound understanding of the biological landscape of the human body and its complexity. Within this landscape, biological membranes stand as critical barriers to the successful delivery of therapeutic cargo to the target site. Their crossing is not only a challenge for nanorobotics but also a pivotal criterion for the clinical success of therapeutic-carrying nanorobots.
View Article and Find Full Text PDFAnal Chem
January 2025
Key Laboratory of Laboratory Medicine, Ministry of Education of China, and Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
An RCA product is a promising scaffold for the construction of DNA nanostructures, but so far, there is no RCA scaffold-based dynamic reconfigurable nanorobot for biological applications. In this contribution, we develop an intracellular stimuli-responsive reconfigurable coiled DNA nanosnake (N-Snake) by using incomplete aptamer-functionalized (A) DNA tetrahedrons (T) to fold a long tandemly repetitive DNA strand synthesized by rolling circle amplification reaction (R) with the help of palindromic fragment (P). A DNA-assembled product, ARTP, including spiked aptamers, can retain the structural integrity even if exposed to fetal bovine serum (FBS) for 24 h and displays substantially enhanced target molecule-dependent cellular internalization efficiency.
View Article and Find Full Text PDFCancer Chemother Pharmacol
January 2025
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, 508126, India.
Introduction: Gynecological cancers, such as ovarian, cervical, and endometrial malignancies, are notoriously challenging due to their intricate biology and the critical need for precise diagnostic and therapeutic approaches. In recent years, groundbreaking advances in nanotechnology and nanobots have emerged as game-changers in this arena, offering the promise of a new paradigm in cancer management. This comprehensive review delves into the revolutionary potential of these technologies, showcasing their ability to transform the landscape of gynecological oncology.
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