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The anti ulcerogenic effect of sildenafil and moringa on ulcers in rats.
Tissue Cell
December 2024
Department of Pharmacology, College of Medicine,University of Baghdad, Iraq; Department of Pharmacology, College of Medicine, University of Baghdad, Iraq. Electronic address:
Article Synopsis
- Moringa and Sildenafil oleifera (MO) may protect against gastric ulcers caused by medication in rats.
- The study tested various groups of rats with one group receiving the ulcer-inducing drug indomethacin, and some receiving the protective effects of either Sildenafil, Moringa, or both beforehand.
- Results showed that Sildenafil and Moringa effectively reduced ulcer severity and inflammation markers, indicating their potential as gastroprotective agents.
Contribution of the community pharmacist workforce to primary care through the lens of medicines classification: comparison of Aotearoa New Zealand and Australia.
J Prim Health Care
December 2024
Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA 6102, Australia.
Introduction Optimal use of the workforce in primary care is critical due to increasing complexity and demand resulting from multi-morbidity in ageing populations. Improving public access to medicines by making them available via a pharmacist without prescription can support self-care while ensuring oversight by a health professional. Aim The aim of this paper was to identify and explore key differences between New Zealand and Australia in medicines classified nationally for pharmacist-only non-prescription supply.
View Article and Find Full Text PDFChanges in provision of extended community pharmacy services in Aotearoa New Zealand, 2018 to 2022.
BMC Health Serv Res
December 2024
Department of Primary Health Care & General Practice, Te Tari Hauora Tūmatanui, University of Otago Wellington, PO Box 7343, Wellington, 6242, New Zealand.
Background: Recognition is growing of the contributions community pharmacists make to the primary health care team, as their role shifts from a traditional dispensing focus to greater emphasis on fully applying their clinical skills. Some extended pharmacist services (e.g.
View Article and Find Full Text PDFSuccessful treatment of megaesophagus with sildenafil in juvenile Pacific harbor seals (Phoca vitulina richardii) undergoing rehabilitation.
Am J Vet Res
December 2024
Vancouver Aquarium, Vancouver, BC, Canada.
Objective: To describe the outcome of megaesophagus in harbor seal pups undergoing rehabilitation from January 2021 to December 2023.
Methods: 5 harbor seal (Phoca vitulina richardii) pups, 2 males and 3 females, were included in the study. All 5 cases had no clinical signs associated with megaesophagus on initial presentation to the rehabilitation facility.
Discovery and Optimization of Dihydroquinolin-2(1)-ones as Novel Highly Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension.
J Med Chem
December 2024
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, P. R. China.
Article Synopsis
- A newly optimized compound showed potent inhibition of PDE5A with an impressive selectivity over other PDE enzymes, indicating strong potential as a treatment option.
- In animal studies, the compound outperformed sildenafil in reducing mean pulmonary artery pressure and right ventricle hypertrophy, suggesting it could be a promising new therapy for PAH.
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