AI Article Synopsis
- The study aimed to determine if two specific mutations in the MYH gene (Y165C and G382D) are linked to a higher risk of breast cancer.
- A total of 691 breast cancer patients and 812 healthy individuals were analyzed for these mutations, revealing that the frequency of the mutations was similar in both groups.
- The findings concluded that having these MYH mutations does not correlate with an increased risk of developing breast cancer.
Article Abstract
Purpose: To explore whether or not there is an association between the presence of either of the germline mutations in the MutY human homologue (MYH) gene (Y165C and G382D) and the risk of breast cancer.
Methods: 691 breast cancer patients and 812 healthy controls were genotyped for the MYH Y165C and G382D mutations. The frequencies of heterozygotes, homozygotes and compound heterozygotes were compared for the two groups.
Results: Four (0.6%) of 691 breast cancer cases carried a MYH Y165C mutant allele, compared to five (0.6%) of the controls (OR 1.1, 95%CI 0.29-4.0, P=0.9). Eight (1.2%) cases carried a MYH G382D mutant allele, compared to eight (1.0%) of the controls (OR 1.2, 95%CI 0.44-3.3, P=0.7). No case or control was homozygous for the variant and none were compound heterozygotes.
Conclusion: Carriers of the MYH Y165C or G382D mutant alleles do not appear to be at increased risk for breast cancer.
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| http://dx.doi.org/10.1007/s10549-008-0042-1 | DOI Listing |
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